Isolation of 4-nerolidylcatechol from leaves of Piper peltatum L., and evaluation of larvicidal activity in mosquito vectors, with emphasis on Aedes aegypti (Diptera: Culicidae).

Synthetic chemical insecticides are widely used in population control of pests. Aedes aegypti is the primary vector of dengue, Zika, chikungunya and yellow fever to humans, and has proven resistance to chemical insecticides. As an alternative vector control method, the ethanolic extract of the leaves of Piper peltatum L. (Piperaceae) showed larvicidal activity against Ae. aegypti. Despite the wide medicinal use of this plant, the biological activity of its isolated constituents remains unexplored. In this sense, we isolated, identified and evaluated the larvicidal activity of 4-nerolidylcatechol (4-NC) from P. peltatum against Ae. aegypti, Culex quinquefasciatus and Anopheles darlingi, focusing on the larvicidal, adulticidal and genotoxic potential of 4-NC on Ae. aegypti.

Bibliographic Details

Main Authors:	NASCIMENTO, S. R. L., PINTO, A. C. da S., MEIRELES, S. da F., SILVA, J. S. da, CHAVES, F. C. M., RAFAEL, M. S.
Other Authors:	SARA RAQUEL LAVAREDA NASCIMENTO, FACULDADE CENTRO UNIVERSITÁRIO DO NORTE; ANA CRISTINA DA SILVA PINTO, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; SABRINA DA FONSECA MEIRELES, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; JUNIELSON SOARES DA SILVA, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; FRANCISCO CELIO MAIA CHAVES, CPAA; MÍRIAM SILVA RAFAEL, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA.
Format:	Artigo de periódico biblioteca
Language:	eng
Published:	2024-06-17
Subjects:	Bioassay, Micronucleus, Artemia franciscana, Dengue, Toxicology,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1164886 https://doi.org/10.1590/1806-9665-RBENT-2023-0074
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