Loss of fshr prevents testicular maturation in Atlantic Salmon (Salmo salar L.).

Early puberty poses a significant challenge for male Atlantic salmon in aquaculture due to its negative impact on growth and welfare. The regulation of puberty in vertebrates involves 2 key reproductive hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and their gonadal receptors. In male mice lacking FSH receptor, testes size is reduced, but fertility is maintained, while medaka and zebrafish with a disrupted fshr gene exhibit near normal testis size and fertility. In these fishes both Fsh and Lh are present during puberty and Lh may rescue fertility, while in salmonid fish only Fsh is present in the circulation during puberty. Using CRISPR-Cas9, we produced crispants with a high prevalence of fshr mutations at the target site, which remained fertile, although more than half showed a testis development deviating from wild-type (wt) males.

Bibliographic Details

Main Authors:	ANDERSSON, E., SCHULZ, R. W., O'SULLIVAN, F. L. A., KLEPPE, L., SKAFTNESMO, K. O., KJÆRNER-SEMB, E., CRESPO, D., FJELLDAL, P. G., HANSEN, T. J., NORBERG, B., EDVARDSEN, R. B., WARGELIUS, A.
Other Authors:	EVA ANDERSSON, INSTITUTE OF MARINE RESEARCH; RÜDIGER W. SCHULZ, INSTITUTE OF MARINE RESEARCH; FERNANDA LOUREIRO ALMEIDA OSULLIVAN, CPAA; LENE KLEPPE, INSTITUTE OF MARINE RESEARCH; KAI OVE SKAFTNESMO, INSTITUTE OF MARINE RESEARCH; ERIK KJÆRNER-SEMB, INSTITUTE OF MARINE RESEARCH; DIEGO CRESPO, INSTITUTE OF MARINE RESEARCH; PER GUNNAR FJELLDAL, INSTITUTE OF MARINE RESEARCH; TOM JOHNNY HANSEN, INSTITUTE OF MARINE RESEARCH; BIRGITTA NORBERG, INSTITUTE OF MARINE RESEARCH; ROLF B. EDVARDSEN, INSTITUTE OF MARINE RESEARCH; ANNA WARGELIUS, INSTITUTE OF MARINE RESEARCH.
Format:	Artigo de periódico biblioteca
Language:	eng
Published:	2024-03-14
Subjects:	Sterility, Aquaculture, Puberty, Salmo salar,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1162834
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