Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep

The integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helminth control.

Bibliographic Details

Main Authors:	NICIURA, S. C. M., CARDOSO, T. F., IBELLI, A. M. G., OKINO, C. H., ANDRADE, B. G., BENAVIDES, M. V., CHAGAS, A. C. de S., ESTEVES, S. N., MINHO, A. P., REGITANO, L. C. de A., GONDRO, C.
Other Authors:	SIMONE CRISTINA MEO NICIURA, CPPSE; TAINÃ FIGUEIREDO CARDOSO; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; CINTIA HIROMI OKINO, CPPSE; BRUNO GABRIEL ANDRADE, Munster Technological University, Cork, Ireland; MAGDA VIEIRA BENAVIDES, CPPSUL; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ALESSANDRO PELEGRINE MINHO, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; CEDRIC GONDRO, Michigan State University, East Lansing, MI, USA.
Format:	Artigo de periódico biblioteca
Language:	eng
Published:	2024-03-05
Subjects:	GWAS, RNA seq, 16S rDNA sequencing, EQTL, Parasite resistance, Barber’s pole worm,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1162588
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