Detection of antileukemia metabolites from P. limosum integrating genome mining, metabolomic analysis and cytotoxicity assays.

Detection of antileukemia metabolites from P. limosum integrating genome mining, metabolomic analysis and cytotoxicity assays.

Chemical dereplication and genome mining approaches were applied to detect cytotoxic metabolites produced by P. limosum CMLD 19 with anticancer potential against human leukemia cells. During the ongoing study, metabolites such as fumitremorgin and triprostatin were detected in the rice extract of P. limosum which showed 80% of cell inhibition for different human leukemia cell lines.

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Bibliographic Details
Main Authors: BASSICHETO, M., OLIVEIRA, C., RIVERO, M., SIPOLONI, V., SOARES, J. K. C., SILVA, G. F. da, JUSTO, G., VEIGA, T., SOMAN, L.
Other Authors: MILENA BASSICHETO, UNIVERSIDADE FEDERAL DE SÃO PAULO; CLÁUDIA OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO PAULO; MILENA RIVERO, UNIVERSIDADE FEDERAL DE SÃO PAULO; VICTOR SIPOLONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; JULLIO KENNEDY CASTRO SOARES, UNIVERSIDADE FEDERAL DE SÃO PAULO; GILVAN FERREIRA DA SILVA, CPAA; GISELLE JUSTO, UNIVERSIDADE FEDERAL DE SÃO PAULO; THIAGO VEIGA, UNIVERSIDADE FEDERAL DE SÃO PAULO; LÍVIA SOMAN, UNIVERSIDADE FEDERAL DE SÃO PAULO.
Format: Resumo em anais e proceedings biblioteca
Language:Ingles
English
Published: 2023-12-14
Subjects:Cytotoxic metabolites, Chemical dereplication, Leukemia, Genome mining,
Online Access:http://www.alice.cnptia.embrapa.br/alice/handle/doc/1159736
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http://www.alice.cnptia.embrapa.br/alice/handle/doc/1159736

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