In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.
The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.
Main Authors: | , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Separatas biblioteca |
Language: | English eng |
Published: |
2015-12-21
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Subjects: | Antiplasmodial, Cytotoxic, Andropogon leucostachyus, Xylopia amazonica, Zanthoxylum djalma-batistae., Anacardium Occidentale, Paullinia Cupana., Croton cajucara, Plasmodium berghei, Plasmodium falciparum, malaria., |
Online Access: | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032178 |
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