Pathogenesis and Treatment of Diabetes Mellitus [electronic resource] /
In this book on diabetes mellitus both the pathogenesis and treat ment of the disease will be discussed. Pathogenetic studies have led to the distinction between type I and type II diabetes. In type I hyperglycaemia is due predominantly to insulin deficiency; in type II insulin resistance is more important. Three pathogenetic factors are thought to play a role in the etiol ogy of type I diabetes: heredity, viral infections and immunity. There may be a relationship between these three aspects since genetic pre disposition changes the susceptibility to viral infections and/or the immunological defence against these infections. Insulitis ensues. Auto immune processes initiated by this chain of events may contribute to the destruction of the B cells in the islets of Langerhans and diabetes -may eventually follow. This means that at the time of the sudden out break of the disease, the destructive process has already been active for years.
Main Authors: | , , , |
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Format: | Texto biblioteca |
Language: | eng |
Published: |
Dordrecht : Springer Netherlands,
1986
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Subjects: | Medicine., Internal medicine., Diabetes., Medicine & Public Health., Internal Medicine., |
Online Access: | http://dx.doi.org/10.1007/978-94-009-4301-8 |
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