Chemistry and Biology of Serpins [electronic resource] /

I. Introduction -- 1. Serpins: From the Way It Was to the Way It Is -- 2. Serpins: A Mechanistic Class of Their Own -- II. Coagulation -- 3. Antithrombin: A Bloody Important Serpin -- 4. Heparin Cofactor II -- 5. PCI: Protein C Inhibitor? -- 6. Molecular Basis for the Resistance of Fibrin-Bound Thrombin to Inactivation by Heparin/Serpin Complexes -- III. Neurobiology and Cancer -- 7. Regulation of Neurons and Astrocytes by Thrombin and Protease Nexin-1: Relationship to Brain Injury -- 8. Maspin: A Tumor Suppressing Serpin -- 9. Proteases and Protease Inhibitors in Tumor Progression -- IV. Fibrinolysis -- 10. The Role of Reactive-Center Loop Mobility in the Serpin Inhibitory Mechanism -- 11. Substrate Specificity of Tissue Type Plasminogen Activator -- 12. Plasminogen Activator Inhibitor Type-2: A Spontaneously Polymerizing Serpin that Exists in Two Topological Forms -- 13. Of Mice and Men: The Function of Plasminogen Activator Inhibitors (PAIs) in Vivo -- V. Development and Reproduction -- 14. Biology of Progesterone-Induced Uterine Serpins -- 15. Serpins from an Insect, Manduca sexta -- 16. The Significance of Serpins in the Regulation of Proteases in the Male Genital Tract -- VI. Inflammation -- 17. Serpins and Programmed Cell Death -- 18. C 1 Inhibitor: Functional Analysis of Naturally-Occurring Mutant Proteins -- 19. Serp-1, a Poxvirus-Encoded Serpin, Is Expressed as a Secreted Glycoprotein that Inhibits the Inflammatory Response to Myxoma Virus Infection -- 20. Dysfunctional Variants and the Structural Biology of the Serpins -- VI. Noninhibitor Serpins -- 21. Structure-Function Studies on PEDF: A Noninhibitory Serpin with Neurotrophic Activity -- 22. Colligin, a Collagen Binding Serpin -- VII. Abstracts -- Coagulation, Neurobiology, and Cancer -- Fibrinolysis, Development, and Reproduction -- Inflammation and Noninhibitor Serpins -- Contributors.

Bibliographic Details

Main Authors:	Church, Frank C. editor., Cunningham, Dennis D. editor., Ginsburg, David. editor., Hoffman, Maureane. editor., Stone, Stuart R. editor., Tollefsen, Douglas M. editor., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Boston, MA : Springer US : Imprint: Springer, 1997
Subjects:	Life sciences., Human genetics., Biochemistry., Animal physiology., Life Sciences., Biochemistry, general., Animal Physiology., Human Genetics.,
Online Access:	http://dx.doi.org/10.1007/978-1-4615-5391-5
Tags:	Add Tag No Tags, Be the first to tag this record!