Mechanisms in B-Cell Neoplasia 1992 [electronic resource] : Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, April 21–23, 1992 /

B-Cell Development -- Progenitor and Precursor B Lymphocytes of Mice. Proliferation and Differentiation In Vitro and Population, Differentiation and Turnover in SCID Mice In Vivo of Normal and Abnormal Cells -- Isolation and Characterization of a Stromal Cell Line -- Growth and Differentiation of a Bipotent Precursor of B Cells and Macrophages -- Control of Intramarrow B-Cell Genesis by Stromal Cell-Derived Molecules -- Establishment of a Reproducible Culture Technique for the Selective Growth of B-Cell Progenitors -- Multiple Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and Stromal Cell Interactions -- The Purification of B-Cell Precursors From Mouse Fetal Liver -- BCR/ABL Enhances Growth of Multipotent Progenitor Cells But Does Not Block Their Differentiation Potential In Vitro -- Repopulation of SCID Mice with Fetal-Derived B-Lineage Cells -- Early B-Cell Repertoires -- In Vitro Growth and Maturation of Human B-Cell Precursors -- Modulation of Signal Transduction in Phosphocholine-Specific B cells from ?? Transgenic Mice -- Immunoglobulin Gene Rearrangement -- Activities Involved in V(D)J Recombination -- Double-Strand Breaks Associated with V(D)J Recombination at the TCR? Locus in Murine Thymocytes -- Replication, Transcription, CpG Methylation and DNA Topology in V(D)J Recombination -- Rearrangement and Expression of Immunoglobulin Genes in Transgenic Mice -- Regulation of Switch Recombination to the Murine ? 1 Gene -- Protein Recognition Motifs of S? 3 DNA Are Statistically Correlated with Switch Recombination Breakpoints -- Regulation of Transcription of the Germline Immunoglobulin ? Constant Region Gene -- S?BP/BSAP/NF-S? B1, a Murine and Human B-Cell Stage Specific Nuclear Factor with DNA Binding Specificity Implying Roles in Switch-Recombination and Transcription -- Multiple Myeloma, Plasmacytomas -- Multidrug Resistance of a Continuously Differentiating Monoclonal B Lineage in the Blood and Bone Marrow of Patients with Multiple Myeloma -- Expression of Multiple Adhesion Molecules on Circulating Monoclonal B Cells in Myeloma -- Circulating Peripheral Blood Plasma Cells in Multiple Myeloma -- Circulating B Lymphocytes in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven Pre-Myeloma Cell Population -- In Which Cells Does Neoplastic Transformation Occur in Myelomatosis? -- Differential Expression of c-myc-mRNA and c-MYC-Protein During Terminal Neoplastic B-Cell Differentiation -- Genes Expressed Selectively in Plasmacytomas: Markers of Differentiation and Transformation -- PCS, a Gene Related to the Immunoglobulin Super Family of Axonal Glycoproteins is Expressed in Murine Plasma Cell Tumors -- Inhibiting IL-6 in Human Multiple Myeloma -- Pathophysiology of Human Multiple Myeloma- Recent Advances and Future Directions -- An Exceptional Mouse Plasmacytoma with a New Kappa/N-myc [T(6; 12) (C1 ; B)] Translocation Expresses N-myc But Not c-myc -- Experimental Model of Human Light-Chain-Associated Disease -- Lymphomas: B-CLL, Follicular Lymphomas BCL-2, BCL-1 -- On the Role of Endogenously Produced TNF-? and IL-6 as Regulators of Growth and Differentiation of B-Type Chronic Lymphocytic Leukemia Cells in Vitro -- BCL-2 in B-Chronic Lymphocytic Leukemia -- Subcellular Localization of BCL-2 Protein -- Collaboration of PIM-1 and BCL-2 in Lymphomagenesis -- The Role of bcl-2 in Lymphoid Differentiation and Neoplastic Transformation -- Evolution of Leukemic Heterogeneity of Human B-CLL Lymphocytes Between and Within Patients -- p53 Mutations in B-Cell Chronic Lymphocytic Leukemia -- Burkitts Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements -- Centrocytic Lymphoma: a B-Cell Non-Hodgkin’s Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements -- Two Surface Antigen Targets for Immunotoxin-Mediated Elimination of Normal and Neoplastic Murine B Cells -- Generation and Differentiation Potential of Retrovirus-lmmortalized Mature Murine B Cells -- The Role of Growth Factors in Human Lymphomas -- Production of Interleukin-6 in High Grade B Lymphomas -- Lymphomas: EBV, AIDS Associated Lymphomas -- Mutational Analysis of the Transforming Function of the EBV Encoded LMP-1 -- Integration of EBV in Burkitt’s Lymphoma Cells -- The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice -- AIDS Associated Non-Hodgkin’s Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal Lymphoproliferative Processes -- Lymphomas in Mice with Retrovirus-lnduced Immunodeficiency -- Does HIV Infection of B Lymphocytes Initiate AIDS Lymphoma? Detection by PCR of Viral Sequences in Lymphoma Tissue -- Oncogenes and Transcriptional Factors -- Lymphocyte Activation and the Family of NF-?B Transcription Factor Complexes -- Transactivation of the c-myc Gene by HTLV-1 tax is Mediated by NF-?B -- Cloning and Characterization of DNA Binding Factors Which Bind Sequences Required for Proper c-myc Initiation -- Transcriptional Activities of the Myc and Max Proteins in Mammalian Cells -- c-myc Transactivates the Ornithine Decarboxylase Gene -- v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis -- Cyclins in the Cell Cycle: An Overview -- The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation -- V-rel and C-rel Modulate the Expression of Both Bursal and Non-Bursal Antigens on Avian B-Cell Lymphomas -- Why Don’t Germline Mutations in RB1 Predispose to Leukemia? -- Loss of p53 Expression in Myc-induced B Lineage Tumors.

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Bibliographic Details
Main Authors: Potter, Michael. editor., Melchers, Fritz. editor., SpringerLink (Online service)
Format: Texto biblioteca
Language:eng
Published: Berlin, Heidelberg : Springer Berlin Heidelberg, 1992
Subjects:Medicine., Immunology., Virology., Allergy., Oncology., Medicine & Public Health., Allergology.,
Online Access:http://dx.doi.org/10.1007/978-3-642-77633-5
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