Selective Activation of Drugs by Redox Processes [electronic resource] /

Characteristics of Hypoxic Cells that Enhance their Susceptibility to Chemical Injury -- Prediction and Measurement of Redox Properties of Drugs and Biomolecules -- Metal-Catalyzed Redox Processes in Biological Systems and Drug Activation -- Redox Systems Generated by Electro-chemical Oxidations and Reductions -- The Rôle of DNA Damage in the Bioreductive Action of 2-Nitroimidazoles -- Redox Properties of Radiation Induced Free Radicals -- Reduction of Bleomycin-Fe by Reductases and Active Oxygen Formation -- Redox Activation of Drugs by the Red Blood Cell Membrane -- Induction of Stress Proteins and Drug Resistance by Hypoxia and Applications of Magnetic Resonance Spectroscopy and Cryospectrophotometry for Detecting Hypoxia in Tumors -- Mechanisms of Activation of Mitomycin C and AZQ in Aerobic and Hypoxic Mammalian Cells -- Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles -- Redox Activation of Benzotriazine N-oxides: Mechanisms and Potential as Anticancer Drugs -- Nitroacridines and Nitroquinolines as DNA-affinic Hypoxia-selective Cytotoxins -- Metabolic Effects of Hypoxic Cell Sensitizers -- Does Ro-03–8799 Concentration in Human Tumour Xenografts Predict Radiosensitization? Comparison with SR-2508 -- Enzyme-directed Bioreductive Drug Development -- Improved Treatment of Tumours in vivo by Combining the Bioreductive Drug, RSU-1069, Hydralazine and Hyperthermia -- Assessment of Bioreductive Drug Toxicity in vitro and in Experimental Tumours in vivo -- Activity of Bioreductive Agents in Human and Rodent Tumor Cells -- The Control of Tumour Oxygenation in Mice: The Importance of Tumour Site -- Critical Events in the Toxicity of Redox Active Drugs -- The Reductive Activation of Nitroimidazoles; Modification by Oxygen and other Redox-active Molecules in Cellular Systems -- Fluorescent Probes for Hypoxia: Chemical Aspects -- Toxicity of Metal Complexes with Radiosensitizing Properties -- Effects on DNA of Bioreducible Nitroimidazole and Benzotriazine Drugs -- Response of Repair and Reduction Deficient Mutants to Agents Requiring Bioreduction -- Bioreductive Drugs and Radiation: Pharmacokinetics and Clinical Trials of Etanidazole Radiosensitizer -- The Oncogenic Potential of Bioreductive Drugs -- Adduct Formation by 2-Nitroimidazole in Mammalian Cells: Optimization of Markers for Tissue Oxygenation -- Tumour Blood Flow and its Modulation: Implications for Bioreductive Drug Activity in vivo -- Poster Presentations -- Participants.

Bibliographic Details

Main Authors:	Adams, G. E. editor., Breccia, A. editor., Fielden, E. M. editor., Wardman, P. editor., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Boston, MA : Springer US : Imprint: Springer, 1990
Subjects:	Medicine., Pharmacology., Oncology., Biochemistry., Medicine & Public Health., Pharmacology/Toxicology., Biochemistry, general.,
Online Access:	http://dx.doi.org/10.1007/978-1-4615-3768-7
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