Serine Proteases and Their Serpin Inhibitors in the Nervous System [electronic resource] : Regulation in Development and in Degenerative and Malignant Disease /

Section I: Biochemistry and Cell Biology of Serine Proteases and Serpins -- 1: Thrombin Structural Regions in Determining Bioregutatory Functions -- 2: Regulation and Control of the Fibrinolytic System -- 3: A Key Molecule Dictating and Regulating Surface Plasmin Formation: The Receptor for Urokinase Plasminogen Activator -- 4: Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells -- 5: Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth -- 6: Structure and Function of Tissue-Type Plasminogen Activator -- 7: The Heparin Binding Site and Activation of Protease Nexin I -- 8: Polypeptide Chain Structure of Inter-?-Trypsin Inhibitor and Pre-?-Trypsin Inhibttor: Evidence for Chain Assembly by Glycan and Comparison with Other “Kunin”-Containing Proteins -- 9: Regulation of Protease Nexin I Activity and Target Protease Specificity by the Extracellular Matrix -- Section II: Molecular Biology of Serine Proteases and Serpins -- 10: Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeeton-Disrupting Agents -- 11: Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and Their Inhibitors: The Thrombin-Hirudin Interaction as an Example -- 12: Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade -- 13: Rodent Serpins: Accelerated Evolution and Novel Specificities -- 14: Structure of the Human Protease Nexin Gene and Expression of Recombinant forms of PNI -- 15: Evolutionary Adaptations of Serpins and Their Use in Designing New Proteinase Inhibitors -- Section III: Serine Proteases in the Nervous System -- 16: Plasminogen Activator in the Developing Nervous System -- 17: Multiple Roles for Plasminogen Activator System in Nervous System Development -- 18: Interaction of Plasminogen Activators with the Neuronal Surface -- 19: Glial Plasminogen Activators in Developing and Regenerating Neural Tissue -- 20: Plasminogen Activators in Development, Injury and Pathology of the Neuromuscular System -- 21: Relationship Between Plasminogen Activators and Regeneration Capacities of Rat Skeletal Muscle -- Section IV: Balance of Proteases and Serpins in the Nervous System -- 22: A Cascade Approach to Synapse Formation Based on Thrombogenic and Fibrinolytic Models -- 23: Localized Extracellular Proteolysis May Convey Inductive Signals Between Nerve and Muscle Cells During Synaptogenesis -- 24: Steps in Establishing a Biological Relevance for Gliaderived Nexin -- Section V: Serpins in Degenerative and Malignant Neurologic Diseases -- 25: Protease Inhibitors in Neurologic Diseases -- 26: Presence and Significance of ?1-Antitrypsin in Human Brain Tumors -- 27: Serpins and Brain Tumors: Roles in Pathogenesis -- 28: A Serine Protease Inhibitor Domain Encoded Within the Alzheimer Disease Associated Amyloid ?-Protein Precursor Gene -- 29: The Serpin, al-Antichymotrypsin, in Brain Aging and Diseases of The Nervous System -- 30: Protease Nexin I Immunostaining in Alzheimer’s Disease -- Section VI: The Maratea Conference -- Photo Layout -- Participants.

Bibliographic Details

Main Authors:	Festoff, Barry W. editor., Hantaï, Daniel. editor., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Boston, MA : Springer New York, 1990
Subjects:	Life sciences., Neurosciences., Biochemistry., Plant science., Botany., Animal anatomy., Life Sciences., Biochemistry, general., Animal Anatomy / Morphology / Histology., Plant Sciences.,
Online Access:	http://dx.doi.org/10.1007/978-1-4684-8357-4
Tags:	Add Tag No Tags, Be the first to tag this record!