The Mobile Receptor Hypothesis [electronic resource] : The Role of Membrane Receptor Lateral Movement in Signal Transduction /

1. Introduction to the Mobile Receptor Hypothesis -- A. The Fluid Mosaic Model of Biological Membranes -- B. The Mobile Receptor Hypothesis -- C. Modern Collision Coupling Theory -- D. Summary and Implications -- 2. Direct Measurement of Lateral Mobility -- A. Introduction -- B. Fluorescence Microscopy -- C. Confocal Microscopy -- D. Fluorescence Photobleaching Recovery -- E. Lateral Mobility in the Cytoplasm and Membranes of Living Cells -- F. Measurements in Artificial and Isolated Membranes -- G. Measurements of Lateral Mobility Using Other Methods -- H. Summary -- 3. Parameters Affecting Plasma Membrane Protein Lateral Mobility -- A. Mechanisms of Protein Immobilization in Biological Membranes -- B. Membrane Lipid Mobility -- C. The Cytoskeleton -- D. Anchorage Modulation -- E. Membrane Protein Sequence Motifs -- F. Domain Structure: Regions of Restricted Mobility -- G. Signal Transduction -- H. Summary -- 4. Lateral Mobility of Polypeptide Hormone Receptors and GTP-Binding Proteins -- A. Introduction -- B. Practical Considerations -- C. Lateral Mobility Measurements of Polypeptide Hormone Receptors -- D. Tyrosine Kinase Receptor-Mediated Signal Transduction -- E. GTP-Binding Protein Activating Receptor-Mediated Signal Transduction -- F. Structural Considerations -- G. Lateral Mobility Measurements of GTP-Binding Proteins -- H. Lateral Mobility of Cytokine Receptors -- I. Summary and Implications for Signal Transduction -- 5. Evidence for the Role of Membrane Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction -- A. Introduction -- B. Kinetic Considerations in GTP-Binding Protein-Mediated Receptor-Effector Systems -- C. Indirect Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction -- D. Direct Evidence for a Role of Receptor Lateral Movement in GTP-Binding Protein-Mediated Signal Transduction -- E. Ga Signaling in the Cytosolic Phase -- F. Stoichiometric Considerations and Trimeric GTP-Binding Protein Immobility -- G. Amplification in GTP-Binding Protein-Mediated Receptor-Effector Systems Through Receptor Lateral Movement -- H. Summary -- 6. Evidence for the Role of Receptor Immobilization in Desensitization Subsequent to Hormonal Stimulation -- A. Introduction -- B. Receptor Internalization in Desensitization of Response -- C. Receptor Immobilization Prior to Internalization -- D. Receptor Movement Required for Internalization -- E. Kinetic Considerations with Respect to Lateral Mobility Measurements -- F. Receptor Phosphorylation -- G. Studies with Receptor Antagonists—Receptor Immobilization Is Agonist-Dependent -- H. Summary -- 7. Evidence for the Role of Immobilization of Ligand-Occupied Membrane Receptors in Signal Transduction -- A. Introduction -- B. Receptor Immobilization in Tyrosine Kinase Receptor Signaling -- C. Receptor Immobilization in Signaling by Fc Receptors -- D. Receptor Immobilization in Cell-Cell Interaction -- E. Receptor Immobilization in Cell-Adhesion to an Extracellular Substratum -- F. Summary -- 8. The Mobile Receptor Hypothesis: A Global View -- A. Introduction -- B. Receptor Lateral Movement in Signal Transduction -- C. The Central Role of the Cytoskeleton -- D. Signal Transduction: Receptor Lateral Mobility Modulation by Heterologous Signaling -- E. Potential Pharmacological Applications of the Mobile Receptor Hypothesis -- F. Concluding Remarks.

Bibliographic Details

Main Authors:	Jans, David A. author., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Boston, MA : Springer US : Imprint: Springer, 1997
Subjects:	Medicine., Ophthalmology., Medicine & Public Health., Medicine/Public Health, general.,
Online Access:	http://dx.doi.org/10.1007/978-1-4757-0680-2
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