Fibrin Sealant in Operative Medicine [electronic resource] : Volume 5: Thoracic Surgery — Cardiovascular Surgery /

Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation. The concept of using clotting substances from human blood for wound manage­ ment and to achieve hemostasis in bleeding parenchymatous organs can be traced to 1909, when Bergel [1] reported on the hemostatic effect of fibrin powder. In 1915, Grey [3] employed fibrin to control bleeding in neurosurgical operations of the brain. A year later, Harvey [4] used fibrin patches to stop bleeding from parenchy­ matous organs in general surgery. It took more than two decades for this ingenious idea to be rediscovered. In 1940, Young and Medawar [8] reported on experimental nerve anastomosis by sealing. Similarly, Tarlov and Benjamin [7] reunited nerves with plasma clots in 1943. Tarlov improved the results obtained with clot anastomosing of nerves by avoiding tension at the nerve stumps. In 1944, Cronkite et al. [2] reported on an initial series of eight cases in which fibrinogen and thrombin had been used successfully for anchoring skin grafts.

Bibliographic Details

Main Authors:	Schlag, Günther. editor., Redl, Heinz. editor., SpringerLink (Online service)
Format:	Texto biblioteca
Language:	eng
Published:	Berlin, Heidelberg : Springer Berlin Heidelberg, 1986
Subjects:	Medicine., Cardiac surgery., Thoracic surgery., Vascular surgery., Medicine & Public Health., Thoracic Surgery., Cardiac Surgery., Vascular Surgery.,
Online Access:	http://dx.doi.org/10.1007/978-3-642-71633-1
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