Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi a scoping review
Trypanosoma cruzi is the etiologic agent of Chagas disease. This fagellated protozoan is transmitted to humans as well as diferent species of domestic and wild animals via vectors from the Reduviidae family (known as kissing bugs). Despite the fact that hundreds of species of wild mammals are part of the reservoir system, the morphological changes and clinical manifestations resulting from the pathogenesis of the infection have been largely neglected. The aim of this review is to systematically compile the available information regarding clinicopathological alterations in wild mammals due to natural infection by T. cruzi. Information was obtained from six online bibliographic data search platforms, resulting in the identifcation of 29 publications that met the inclusion criteria. Mortality was the most common clinical manifestation, cardiac damage was the main fnding at necropsy, and lymphoplasmacytic infammation was the most frequent microscopic injury. Thus, regardless of its role as a reservoir, T. cruzi has the potential to afect the health status of wild mammals, a situation that highlights the need for further research to analyze, measure, and compare its efects at both the individual and population levels.
| Main Authors: | , , , |
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| Format: | Texto biblioteca |
| Language: | eng |
| Subjects: | Trypanosoma cruzi, Enfermedad de chagas, Mamíferos silvestres, Zoonosis, |
| Online Access: | https://doi.org/10.1186/s44149-024-00111-4 |
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