In utero exposure to the antiandrogen 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México

The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital distance serves as a measure of fetal androgen action. The authors designed the present study to examine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males. A cross-sectional study of 781 newly delivered male infants was conducted in 2002-2003 in Chiapas, México, where DDT had recently been used for malaria control.

Bibliographic Details

Main Authors:	Longnecker, Matthew P., Gladen, Beth C. autor/a, Cupul Uicab, Lea A. autor/a, Romano Riquer, S. Patricia autor/a, Weber, Jean Phillipe autor/a, Chapin, Robert E. autor/a, Hernández Ávila, Mauricio Doctor autor/a 7183
Format:	Texto biblioteca
Language:	eng
Subjects:	Diclorodifenil dicloroetileno, DDT (Insecticida), Enfermedades del sistema endocrino, Artfrosur,
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