Self-association of caffeine and theophylline and the interaction of caffeine with adenine

The central stimulating effect of methylxanthines, especially caffeine and theophylline, most probably involved blockade of adenosine receptors. Adenosine is an important modulator of synaptic activity in the central nervous system (CNS), as it exerts depressant effects on neuronal firing rates. In the case that similarities in intermolecular interaction between adenosine receptors in the CNS and adenine (purine part of adenosine) respectively caffeine (or theophylline) are relevant, also interaction between adenine and the methylxanthines should occur in aqueous solution. We have studied in detail the energetics of the molecular self-association of caffeine and theophylline in solution by a variety of thermochemical methods. These methods include measurement of: solubilities over a wide range of temperatures; solution densities as a function of concentration and temperature to obtain partial molar volumes in solution; heats of dissolution, dilution and mixing; osmotic coefficients

Bibliographic Details

Main Authors:	53323 Cammenga, H.K., 50388 Bothe, H., 121683 Steppuhn, I., 121684 Steppuhn, M., 3180 Association Scientifique Internationale du Café, París (Francia), 32077 12. International Scientific Colloquium on Coffee Montreal (Canadá) 29 Jun - 3 Jul 1987
Format:	biblioteca
Published:	París (Francia) 1988
Subjects:	CAFE, CAFEINA, TEOFILINA, ADENINA, COMPUESTOS ORGANICOS,
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