Brucella protective antigens: present and future
The peptidoglycan rich cell-wall fraction obtained after boiling cell-wall in a SDS solution contained all the protective antigens when compared to the reference H38 vaccine in the mouse model for vaccine control. This fraction is composed of two major groups of protein and glycoprotein at 36-38 K and 25-27 K respectively, and of two minor proteins at 31 K and 15 K, and an unknown quantity of S-LPS. Passive protective immunity show that: i) humoral immunity is part of protective immunity in Brucellosis, ii) at least two types of antigens are involved in the protective humoral immunity: S-LPS and one or more antigens present in the PG fraction. Antigens involved in the cellular part of protective immunity are not identified but they are located in PG fraction. These results are briefly discussed according to new available powerful technologies (gene cloning, synthetic vaccines) for making an ideal Brucella vaccine
| Main Authors: | , , , |
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| Format: | biblioteca |
| Published: |
Dordrecht (Países Bajos) Martinus Nijhoff
1985
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| Subjects: | BRUCELOSIS, BRUCELLA, ANTIGENOS, INMUNIDAD, VACUNA, |
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