A rational approach in finding chemicals for control of resistant green rice leafhopper
The green rice leafhopper has developed cross-resistance to many N-methylcarbamate insecticides due to the reduced sensitivity of its acetylcholinesterase (AChE) to the carbamates. Intentional design of carbamate compounds which hopefully interact with 'altered' AChE resulted in the discovery of N-propylcarbamates as potent inhibitors of AChE from the resistant hopper, which, however, remain as poor insecticides. Combination of the N-propylcarbamate with N-methylcarbamate with the same or different phenyl grouping gives a potent synergistic insecticidal activity. The mechanism is elucidated on biochemical basis. The AChE from resistant hopper has the additional inhibition site which is sensitive to N-propyl but insensitive to N-methylcarbamates other than the N-methylcarbamate-sensitive site present in AChE from susceptible hopper. Single inhibitor can not inhibit both sites, but by combining two inhibitors, each interacts with the preferred site. Recognition of such mechanism provides the chance for finding other chemicals and a rational basis for the use of combined anti-AchEs
| Main Authors: | , , |
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| Format: | biblioteca |
| Published: |
Taiwan (Taiwan)
1979
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| Subjects: | ARROZ, INSECTOS DANINOS, INSECTICIDAS, CONTROL DE INSECTOS, NEPHOTETTIX, NEPHOTETTIX CINCTICEPS, |
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