Inhibition of hepatitis B virus-dependent DNA polymerase by species of Phyllanthus; genetic and environmental effects on this activity
Results of studies to identify the best genotypes of Phyllanthus and/or optimum conditions for producing plants with a high level of hepatitis B viral DNA polymerase (DNAp) inhibition are reported. Analysis of traditional medicinal uses of Phyllanthus species to treat jaundice showed that a significantly higher number of these species belonged to the subgenus Phyllanthus than to all the other 9 subgenera combined. Interspecific variation for the character was found. P. amarus had the highest viral DNAp inhibition and little intraspecific genetic variation. Low temperatures dramatically decreased viral DNAp inhibition. Plants grown in arid areas were more potent inhibitors than those grown in humid areas. No activity differences were observed betweenplant ages and organs. Cultivated plants had similar activity to wild plants. The exact relation between inhibition of viral DNAp in vitro and anti-viral activity in vivo was not identified.
| Main Authors: | , , , |
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| Format: | biblioteca |
| Published: |
1991
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| Subjects: | PLANTAS MEDICINALES, VIRICIDAS, PROPIEDADES ANTIMICROBIANAS, VIRUS, HEPATITIS, INHIBICION, RECURSOS GENETICOS, |
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