Modelling American Trypanosomiasis in an endemic zone application to the initial spread of household infection in the Argentine Chaco
Summary: The complex dynamics of Trypanosoma cruzi infection [Chagas disease] involves different actors and multiple transmission routes. Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathematical deterministic model was formulated considering: [i] the three clinical forms in humans: acute, chronic indeterminate and chronic with determinate pathology, [ii] the three main modes of transmission in the human population: vector-borne, congenital and transfusional, [iii] populations of triatomines and dogs as the main domestic reservoirs of T. cruzi and [iv] open populations. A numerical simulation was also performed to estimate the initial spread of the infection in a typical rural household in the endemic zone of the Argentine Gran Chaco. We also analysed the incidence of infected individuals corresponding to each of the three species [humans/triatomines/dogs] over times until the appearance of the first case in the other species. The model predicts that, in the absence of control measures, a few infected individuals are sufficient for the establishment and dispersion of the infection in all the inhabitants of the household. The model proposed and the results obtained allow describing the consequences of the presence of infected individuals in any of the three species considered in the dynamics and the output of the infection.
| Main Authors: | , , |
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| Format: | Texto biblioteca |
| Language: | spa |
| Subjects: | CANIS FAMILIARIS, DOGS, HOUSEHOLD INFECTION, MATHEMATICAL MODEL, TRIATOMINES, TRYPANOSOMA CRUZI, TRYPANOSOMA CRUZI INFECTION, |
| Online Access: | http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber=47136 http://ceiba.agro.uba.ar/cgi-bin/koha/opac-detail.pl?biblionumber= |
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