Unraveling the physicochemical determinants of protein liquid-liquid phase separation by nanoscale infrared vibrational spectroscopy

by Ruggeri, Francesco S., Miller, Alyssa M., Vendruscolo, Michele, Knowles, Tuomas P.J.

Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils

by Miller, Alyssa, Chia, Sean, Klimont, Ewa, Knowles, Tuomas P.J., Vendruscolo, Michele, Ruggeri, Francesco Simone

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

by Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P.J.

Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

by Miller, Alyssa, Wei, Jiapeng, Meehan, Sarah, Dobson, Christopher M., Welland, Mark E., Klenerman, David, Vendruscolo, Michele, Ruggeri, Francesco Simone, Knowles, Tuomas P.J.

Enhanced surface nanoanalytics of transient biomolecular processes

by Miller, Alyssa, Chia, Sean, Toprakcioglu, Zenon, Hakala, Tuuli, Schmid, Roman, Feng, Yaduo, Kartanas, Tadas, Kamada, Ayaka, Vendruscolo, Michele, Ruggeri, Francesco Simone, Knowles, Tuomas P.J.

Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease

by Sideris, Dimitrios I., Danial, John S.H., Emin, Derya, Ruggeri, Francesco S., Xia, Zengjie, Zhang, Yu P., Lobanova, Evgeniia, Dakin, Helen, De, Suman, Miller, Alyssa, Sang, Jason C., Knowles, Tuomas P.J., Vendruscolo, Michele, Fraser, Graham, Crowther, Damian, Klenerman, David

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease.

by Emin, Derya, Zhang, Yu P., Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I., Lam, Jeff Y.L., Ranasinghe, Rohan T., Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas P.J., Vendruscolo, Michele, Ruggeri, Francesco S., Aigbirhio, Franklin I., Williams-Gray, Caroline H., Klenerman, David

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

by Limbocker, Ryan, Staats, Roxine, Chia, Sean, Ruggeri, Francesco S., Mannini, Benedetta, Xu, Catherine K., Perni, Michele, Cascella, Roberta, Bigi, Alessandra, Sasser, Liam R., Block, Natalie R., Wright, Aidan K., Kreiser, Ryan P., Custy, Edward T., Meisl, Georg, Errico, Silvia, Habchi, Johnny, Flagmeier, Patrick, Kartanas, Tadas, Hollows, Jared E., Nguyen, Lam T., LeForte, Kathleen, Barbut, Denise, Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Knowles, Tuomas P.J., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele