Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays

by Zhang, Mengying, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M.

Predictive Performance of Next Generation Physiologically Based Kinetic (PBK) Model Predictions in Rats Based on In Vitro and In Silico Input Data

by Punt, Ans, Louisse, Jochem, Pinckaers, Nicole, Fabian, Eric, van Ravenzwaay, Bennard

Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat

by Noorlander, Annelies, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M., van Ravenzwaay, Bennard

Predicting acute paraquat toxicity using physiologically based kinetic modelling incorporating in vitro active renal excretion via the OCT2 transporter

by Noorlander, Annelies, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M., van Ravenzwaay, Bennard

Use of Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict in Vivo Acute Toxicity of Tetrodotoxin in Rodents

by Noorlander, Annelies, Zhang, Mengying, Van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M.

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide

by Noorlander, Annelies, Fabian, Eric, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M.

Towards a generic physiologically based kinetic model to predict in vivo uterotrophic responses in rats by reverse dosimetry of in vitro estrogenicity data

by Zhang, Mengying, van Ravenzwaay, Bennard, Fabian, Eric, Rietjens, Ivonne M.C.M., Louisse, Jochem

In vitro models to measure effects on intestinal deconjugation and transport of mixtures of bile acids

by Zhang, Nina, Zheng, Weijia, Bakker, Wouter, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M.

Corrigendum to ‘Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis’

by Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis

by Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen L.A., van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture

by Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen L.A., van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M., Piersma, Aldert H.

In vitro models to detect in vivo bile acid changes induced by antibiotics

by Zhang, Nina, Wang, Jingxuan, Bakker, Wouter, Zheng, Weijia, Baccaro, Marta, Murali, Aishwarya, van Ravenzwaay, Bennard, Rietjens, Ivonne M.C.M.

Antibiotic-induced changes in microbiome-related metabolites and bile acids in rat plasma

by de Bruijn, Véronique, Behr, Christina, Sperber, Saskia, Walk, Tilmann, Ternes, Philipp, Slopianka, Markus, Haake, Volker, Beekmann, Karsten, van Ravenzwaay, Bennard

The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategy

by Adam, Aziza Hussein Bakheit, Zhang, Mengying, de Haan, Laura H.J., van Ravenzwaay, Bennard, Louisse, Jochem, Rietjens, Ivonne M.C.M.

Predictive performance of next generation human physiologically based kinetic (PBK) models based on in vitro and in silico input data

by Punt, Ans, Louisse, Jochem, Beekmann, Karsten, Pinckaers, Nicole, Fabian, Eric, Van Ravenzwaay, Bennard, Carmichael, Paul L., Sorrell, Ian, Moxon, Thomas E.

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

by Dimopoulou, Myrto, Verhoef, Aart, Gomes, Caroline A., van Dongen, Catharina W., Rietjens, Ivonne M.C.M., Piersma, Aldert H., van Ravenzwaay, Bennard

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

by Botham, Philip, Cronin, Mark T.D., Currie, Richard, Doe, John, Funk-Weyer, Dorothee, Gant, Timothy W., Leist, Marcel, Marty, Sue, van Ravenzwaay, Bennard, Westmoreland, Carl

Connecting Gut Microbial Diversity with Plasma Metabolome and Fecal Bile Acid Changes Induced by the Antibiotics Tobramycin and Colistin Sulfate

by Murali, Aishwarya, Giri, Varun, Zickgraf, Franziska Maria, Ternes, Philipp, Cameron, Hunter James, Sperber, Saskia, Haake, Volker, Driemert, Peter, Kamp, Hennicke, Funk-Weyer, Dorothee, Sturla, Shana J., Rietjens, Ivonne M.C.M., van Ravenzwaay, Bennard

Gut Microbiota as Well as Metabolomes of Wistar Rats Recover within Two Weeks after Doripenem Antibiotic Treatment

by Murali, Aishwarya, Zickgraf, Franziska Maria, Ternes, Philipp, Giri, Varun, Cameron, Hunter James, Sperber, Saskia, Haake, Volker, Driemert, Peter, Kamp, Hennicke, Weyer, Dorothee Funk, Sturla, Shana J., Rietjens, Ivonne M.G.M., van Ravenzwaay, Bennard

New approach methodologies in human regulatory toxicology – Not if, but how and when!

by Schmeisser, Sebastian, Miccoli, Andrea, von Bergen, Martin, Berggren, Elisabet, Braeuning, Albert, Busch, Wibke, Desaintes, Christian, Gourmelon, Anne, Grafström, Roland, Harrill, Joshua, Hartung, Thomas, Herzler, Matthias, Kass, Georges, Kleinstreuer, Nicole, Leist, Marcel, Luijten, Mirjam, Marx-Stoelting, Philip, Poetz, Oliver, van Ravenzwaay, Bennard, Roggeband, Rob, Rogiers, Vera, Roth, Adrian, Sanders, Pascal, Thomas, Russell S., Marie Vinggaard, Anne, Vinken, Mathieu, van de Water, Bob, Luch, Andreas, Tralau, Tewes