Ana Domingos
Ana I. Domingos is a Portuguese neuroscientist specialising in the treatment of obesity independently of food intake. Domingos is a full Professor of Neuroscience at the Department of Physiology, Anatomy and Genetics of the University of Oxford in the United Kingdom. Domingos is also a fellow, tutor and the director of studies in medicine at Lady Margaret Hall, Oxford.A trained mathematician, Domingos began her research career by pursuing a Ph.D in neurobiology at Rockefeller University. Supervised by Leslie Voshall, Domingos studied the sensory systems facilitating our sense of smell. As a post-doctoral research scientist, Domingos worked under Jeffrey Friedman, investigating how ones metabolism can influence the brain circuitry involved in sweetener cravings.
Domingos founded her own laboratory in the [https://gulbenkian.pt/ciencia/homepage/igc/missao-visao-e-valores/ Gulbenkian Institute] in Portugal where she made a number of key discoveries. Firstly, her laboratory discovered that a hormone produced by fat, called leptin, interacts with the sympathetic nerves to control fat breakdown. Sympathetic nerves release a hormone called noradrenaline which is received by a molecular switch expressed by fat tissue, called a β-2 receptor. Activation of the β-2 receptor or "switch" causes the fat tissue to "burn off" as heat. Secondly, her laboratory was able to visualize how sympathetic neurons connect with fat tissue. Thirdly, the Domingos laboratory studied how "Pac-Man-like" immune cells close to sympathetic neurons, dubbed sympathetic associated macrophages, could contribute to obesity by absorbing the noradrenergic chemical signals sent by the sympathetic neurons to fat tissue.
Sympathomimetic drugs behave like the chemical signals produced by sympathetic neurons interacting with fat. Collaborating with scientists in The University of Cambridge, the Domingos' lab in Oxford hopes to improve upon sympathomimetics, by producing a class of compounds that do not interact with the central nervous or cardiovascular systems, thereby limiting side effects. These new and improved compounds are dubbed sympathofacilitators. To this end, the Domingos' group studies the circuit properties of sympathetic neural networks interact with fat and how they are regulated by immune cells, pioneering a new field of research coined ''Neuroimmunometabolism'' on which her lab has authored [https://www.sciencedirect.com/science/article/abs/pii/S0896627322009461 reviews]. Provided by Wikipedia
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6by Hohlfeldt,Antonio, Domingos,Ana Cláudia Munari, Silva,Taíssi Alessandra Cardoso da
Published 2017Digital revistaSCIELO -
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8by Barreto,Sara, Domingos,Ana, Navarro,David, Góis,Mário, Sousa,Helena, Nolasco,Fernando
Published 2019Digital revistaSCIELO -
9by Moura,Maria Aparecida Vasconcelos, Domingos,Ana Maria, Rassy,Maria Elizabete de Castro
Published 2010Digital revistaSCIELO -
10Digital revistaSCIELO
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11by Maia,Ana Filipa, Inácio,Catarina, Domingos,Ana Sofia, Solinho,Mariana, Estrela,Margarida
Published 2024Digital revistaSCIELO -
12by Domingos,Ana, Vidinha,Joana, Guedes,Anabela, Macedo,Ana, Góis,Mário, Neves,Pedro Leão
Published 2020Digital revistaSCIELO -
13by Marques,Roberto C., Carias,Eduarda C., Domingos,Ana T., Guedes,Anabela M., Bernardo,Idalécio, Neves,Pedro L.
Published 2021Digital revistaSCIELO -
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15by Bonini-Domingos,Claudia R., Bonini-Domingos,Ana C., Chinelato,Ana R., Zamaro,Paula J. A., Calderan,Patrícia H. O.
Published 2003Digital revistaSCIELO -
16by Gomes Domingos,Ana Luiza, Lins Machado-Coelho,George Luiz, Pinheiro Volp,Ana Carolina, Pereira de Oliveira,Fernando Luiz, Santana Caldas,Ivo, Nascimento de Freitas,Silvia
Published 2014Digital revistaSCIELO -
17by Domingos,Ana Luiza Gomes, Hermsdorff,Helen Hermana Miranda, Mendes,Larissa Loures, Oliveira,Fernando Luiz Pereira de, Oliveira,Anderson Castro Soares de, Pimenta,Adriano Marçal, Bressan,Josefina
Published 2022Digital revistaSCIELO -
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19by Estrada-Peña, Agustín, Nava, Santiago, Tarragona, Evelina Luisa, Bermúdez, Sergio, de la Fuente, José, Domingos, Ana, Labruna, Marcelo B., Mosqueda, Juan, Merino, Octavio, Szabó, Matías P.J., Venzal, José Manuel, Guglielmone, Alberto
Published 2019-12info:ar-repo/semantics/artículo bibliotecaINTA AR -
20by Estrada-Peña, Agustín, Rodriguez Mallon, Alina, Bermudez, Sergio, Domingos, Ana, Estrada Garcia, Mario Pablo, Labruna, Marcelo B., Merino, Octavio, Nava, Santiago, Tarragona, Evelina Luisa, Venzal, José Manuel, de La Fuente, José, Mosqueda, Juan, Lleonart Cruz, Ricardo
Published 2022-10info:ar-repo/semantics/artículo bibliotecaINTA AR