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The Role of Kinetics as Key Determinant in Toxicity of Pyrrolizidine Alkaloids and Their N-Oxides

by Widjaja, Frances, Alhejji, Yasser, Rietjens, Ivonne M.C.M.

Article/Letter to editor biblioteca

WUR NL

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Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

by Widjaja, Frances, Alhejji, Yasser, Yangchen, Jamyang, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M.

Article/Letter to editor biblioteca

WUR NL

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$In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids$

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrro...

by Alhejji, Yasser, Widjaja, Frances, Tian, Shenghan, Hoekstra, Thomas, Wesseling, Sebastiaan, Rietjens, Ivonne M.C.M.

Article/Letter to editor biblioteca

WUR NL

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