Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin

Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin

Show other versions (1)

Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Química de Biomoléculas. Buenos Aires, Argentina.

Saved in:
Bibliographic Details
Main Authors: Fernández, Paula Virginia, Quintana, Irene, Cerezo, Alberto S., Caramelo, Julio J., Pol Fachin, Laercio, Verli, Hugo, Estevez, José Manuel, Ciancia, Marina
Format: article biblioteca
Language:eng
Subjects:ANTICOAGULANT ACTIVITIES, AMINO ACID RESIDUES, ARABINANS, SULFATED POLYSACCHARIDES,
Online Access:http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013fernandez
Tags: Add Tag
No Tags, Be the first to tag this record!
id snrd:2013fernandez
record_format koha
spelling snrd:2013fernandez2021-10-15T16:56:07Z Fernández, Paula Virginia Quintana, Irene Cerezo, Alberto S. Caramelo, Julio J. Pol Fachin, Laercio Verli, Hugo Estevez, José Manuel Ciancia, Marina 2013 Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Química de Biomoléculas. Buenos Aires, Argentina. Fil: Quintana, Irene. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Hemostasia y Trombosis. Buenos Aires, Argentina. Fil: Cerezo, Alberto S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica. Subsede del Centro de Investigación de Hidratos de Carbono (CIHIDECAR). Ciudad Universitaria, Buenos Aires, Argentina. Fil: Caramelo, Julio J. CONICET - Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA). Buenos Aires, Argentina. Fil: Pol Fachin, Laercio. Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Programa de Pos-Graduação em Biologia Celular e Molecular. Centro de Biotecnologia. Rio Grande do Sul, Brasil. Fil: Verli, Hugo. Universidade Federal do Rio Grande do Sul.Centro de Biotecnologia. Programa de Pos-Graduação em Biologia Celular e Molecular. Rio Grande do Sul, Brasil. Fil: Estevez, José Manuel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias (IFIByNE). Buenos Aires, Argentina. Fil: Ciancia, Marina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Química de Biomoléculas. Buenos Aires, Argentina. Background: Many seaweed polysaccharides have anticoagulant activity, but the mechanism of action was elucidated in a few cases.\nResults: A highly sulfated pyranosic ß-arabinan exerts its activity through direct and indirect inhibition of thrombin.\nConclusion: The structure and mechanism of action of the arabinan are different from those found for other polysaccharides.\nSignificance: This arabinan could be an alternative anticoagulant in certain specific cases. tbls., grafs. application/pdf 10.1074/jbc.M112.386441 0021-9258 http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013fernandez eng info:eu-repo/semantics/openAccess openAccess http://ri.agro.uba.ar/greenstone3/library/page/biblioteca#section4 The journal of biological chemistry Vol.288, no.1 223–233 https://www.asbmb.org ANTICOAGULANT ACTIVITIES AMINO ACID RESIDUES ARABINANS SULFATED POLYSACCHARIDES Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin article info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion publishedVersion
institution UBA
collection DSpace
country Argentina
countrycode AR
component Bibliográfico
access En linea
databasecode dig-ubafa
tag biblioteca
region America del Sur
libraryname Biblioteca Facultad de Agronomía
language eng
topic ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
spellingShingle ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estevez, José Manuel
Ciancia, Marina
Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
description Fil: Fernández, Paula Virginia. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Biología Aplicada y Alimentos. Cátedra de Química de Biomoléculas. Buenos Aires, Argentina.
format article
topic_facet ANTICOAGULANT ACTIVITIES
AMINO ACID RESIDUES
ARABINANS
SULFATED POLYSACCHARIDES
author Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estevez, José Manuel
Ciancia, Marina
author_facet Fernández, Paula Virginia
Quintana, Irene
Cerezo, Alberto S.
Caramelo, Julio J.
Pol Fachin, Laercio
Verli, Hugo
Estevez, José Manuel
Ciancia, Marina
author_sort Fernández, Paula Virginia
title Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_short Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_full Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_fullStr Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_full_unstemmed Anticoagulant Activity of a Unique Sulfated Pyranosic (133) - ß - L - Arabinan through Direct Interaction with Thrombin
title_sort anticoagulant activity of a unique sulfated pyranosic (133) - ß - l - arabinan through direct interaction with thrombin
url http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2013fernandez
work_keys_str_mv AT fernandezpaulavirginia anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT quintanairene anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT cerezoalbertos anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT caramelojulioj anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT polfachinlaercio anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT verlihugo anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT estevezjosemanuel anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
AT cianciamarina anticoagulantactivityofauniquesulfatedpyranosic133ßlarabinanthroughdirectinteractionwiththrombin
_version_ 1756546280197193728

Similar Items