Cytotoxic evaluation of fractions obtained from marines sponges from the colombian Caribbean Amphimedon compressa, Cinachyrella kuekenthali, Svenzea zeai e Ircinia campana
In the search for antitumor activity in drug development is necessary to evaluate preliminary the cytotoxic activity, in order to search for other activities as antitproliferative and genotoxic potential effect. The evaluation of dierent fractions obtained from marine sponges from Colombian Caribbean has been found antiproliferative activity in some of them. Therefore, in this study we evaluated the cytotoxic activity of thirteen fractions obtained from marine sponges Amphimedon compressa, Cinachyrella kuekenthali, Svenzea zeai and Ircinia campana were evaluated to determine their cytotoxic potential in Jurkat clone E6-1 cells, and cell line CHO-K1. The techniques used were MTT test and trypan blue assay to assess cytotoxicity and viability in order to determine their half inhibitory concentration. Results show that no single fraction has signicant cytotoxic activity.
Main Authors: | Estrada Ortiz, Natalia, López Ortiz, Juan Bautista, Márquez, Diana M., Martínez, Alejandro, Márquez Fernández, María Elena |
---|---|
Format: | Digital revista |
Language: | spa |
Published: |
Universidad Nacional de Colombia - Sede Medellín - Facultad de Ciencias
2013
|
Online Access: | https://revistas.unal.edu.co/index.php/rfc/article/view/49177 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The isolation and biological activity of secondary metabolites from the Jamaican sponges neofibularia nolitangere, Iotrochota and amphimedon compressa
by: Thompson, Monique Natasha -
Cytotoxic evaluation of fractions from the Colombian Caribbean sea sponge Topsentia ophiraphidites
by: Blandón, Lina, et al.
Published: (2013) -
CYTOTOXIC CONSTITUENTS FROM THE ROOT WOOD OF FORMOSAN MICHELIA COMPRESSA
by: LIU,CHIA-YUAN, et al.
Published: (2008) -
Cytotoxic activity of hexane and dichloromethane parts of methanol extract of Ircinia mutans sponge on three human cancer cell lines
by: Heidary Jamebozorgi, F., et al.
Published: (2018) -
Ichthyotoxic, cytotoxic and antimicrobial activity of some sponges of the Colombian Caribbean
by: Zea, S., et al.
Published: (1986)