Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective
Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan.
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Frontiers Media
2023
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Subjects: | SINDROME METABOLICO, NEUROPROTECCION, NEURODESARROLLO, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/17275 |
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oai:ucacris:123456789-172752024-02-08T19:12:02Z Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective Kobiec, Tamara Mardaraz, Claudia Toro Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco Otero Losada, Matilde SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan. 2023-10-12T10:44:51Z 2023-10-12T10:44:51Z 2023 Artículo Kobiec, T. Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective [en línea]. Frontiers in Neuroscience. 2023, 17: 1214468. doi: 10.3389/fnins.2023.1214468 . Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17275 1662-453X (online) https://repositorio.uca.edu.ar/handle/123456789/17275 10.3389/fnins.2023.1214468 eng Neuroprotección en asfixia perinatal desde un enfoque traslacional Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Frontiers in Neuroscience. Vol.17: 1214468, 2023 |
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SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO |
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SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO Kobiec, Tamara Mardaraz, Claudia Toro Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco Otero Losada, Matilde Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
description |
Abstract: Metabolic syndrome (MetS) is defined by the concurrence of different metabolic
conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence
has been increasingly rising over the past decades and has become a global health
problem. MetS has deleterious consequences on the central nervous system (CNS)
and neurological development. MetS can last several years or be lifelong, affecting
the CNS in different ways and treatments can help manage condition, though
there is no known cure. The early childhood years are extremely important in
neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic
changes take place all life through — childhood, adolescence, adulthood, and old
age — are highly sensitive to environmental input. Environmental factors have an
important role in the etiopathogenesis and treatment of MetS, so environmental
enrichment (EE) stands as a promising non-invasive therapeutic approach. While
the EE paradigm has been designed for animal housing, its principles can be and
actually are applied in cognitive, sensory, social, and physical stimulation programs
for humans. Here, we briefly review the central milestones in neurodevelopment
at each life stage, along with the research studies carried out on how MetS affects
neurodevelopment at each life stage and the contributions that EE models can
provide to improve health over the lifespan. |
format |
Artículo |
topic_facet |
SINDROME METABOLICO NEUROPROTECCION NEURODESARROLLO |
author |
Kobiec, Tamara Mardaraz, Claudia Toro Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco Otero Losada, Matilde |
author_facet |
Kobiec, Tamara Mardaraz, Claudia Toro Urrego, Nicolás Kölliker Frers, Rodolfo Capani, Francisco Otero Losada, Matilde |
author_sort |
Kobiec, Tamara |
title |
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
title_short |
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
title_full |
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
title_fullStr |
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
title_full_unstemmed |
Neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
title_sort |
neuroprotection in metabolic syndrome by environmental enrichment: a lifespan perspective |
publisher |
Frontiers Media |
publishDate |
2023 |
url |
https://repositorio.uca.edu.ar/handle/123456789/17275 |
work_keys_str_mv |
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