Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis
Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye.
Main Authors: | , , , , , |
---|---|
Format: | Artículo biblioteca |
Language: | eng eng |
Published: |
2010
|
Subjects: | MELATONINA, OFTALMOLOGIA, RECEPTORES DE MELATONINA, ESTRES OXIDATIVO, OJOS, GLAUCOMA, UVEITIS, APLICACIONES TERAPEUTICAS, |
Online Access: | https://repositorio.uca.edu.ar/handle/123456789/1666 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:ucacris:123456789-1666 |
---|---|
record_format |
koha |
spelling |
oai:ucacris:123456789-16662020-08-19T21:51:55Z Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis Rosenstein, Ruth E. Pandi Perumal, Seithikurippu R. Srinivasan, Venkataramanujan Spence, David Warren Brown, Gregory M. Cardinali, Daniel Pedro MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye. 2019-05-02T14:01:20Z 2019-05-02T14:01:20Z 2010 Artículo Rosenstein, R. E., et al. Melatonin as a therapeutic tool in ophthalmology : implication for glaucoma and uveitis [en línea]. Preprint de artículo publicado en Journal of Pineal Research. 2010, 49 (1). doi:10.1111/j.1600-079X.2010.00764.x. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1666 https://repositorio.uca.edu.ar/handle/123456789/1666 10.1111/j.1600-079X.2010.00764.x 20492443 eng eng Acceso Abierto https://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Journal of Pineal Research. 2010, 49 (1) |
institution |
UCA |
collection |
DSpace |
country |
Argentina |
countrycode |
AR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-uca |
tag |
biblioteca |
region |
America del Sur |
libraryname |
Sistema de bibliotecas de la UCA |
language |
eng eng |
topic |
MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS |
spellingShingle |
MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS Rosenstein, Ruth E. Pandi Perumal, Seithikurippu R. Srinivasan, Venkataramanujan Spence, David Warren Brown, Gregory M. Cardinali, Daniel Pedro Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
description |
Abstract: Several lines of evidence support the view that increased free radical generation and altered nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular diseases, such as glaucoma and uveitis. Data are discussed indicating that melatonin, being an efficient antioxidant that displays antinitridergic properties, has a promising role in the treatment of these ocular dysfunctions. Melatonin synthesis occurs in the eye of most species and melatonin receptors are localized in different ocular structures. In view of the fact that melatonin lacks significant adverse collateral effects even at high doses, the application of melatonin could potentially protect ocular tissues by effectively scavenging free radicals and excessive amounts of NO generated in the glaucomatous or uveitic eye. |
format |
Artículo |
topic_facet |
MELATONINA OFTALMOLOGIA RECEPTORES DE MELATONINA ESTRES OXIDATIVO OJOS GLAUCOMA UVEITIS APLICACIONES TERAPEUTICAS |
author |
Rosenstein, Ruth E. Pandi Perumal, Seithikurippu R. Srinivasan, Venkataramanujan Spence, David Warren Brown, Gregory M. Cardinali, Daniel Pedro |
author_facet |
Rosenstein, Ruth E. Pandi Perumal, Seithikurippu R. Srinivasan, Venkataramanujan Spence, David Warren Brown, Gregory M. Cardinali, Daniel Pedro |
author_sort |
Rosenstein, Ruth E. |
title |
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
title_short |
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
title_full |
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
title_fullStr |
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
title_full_unstemmed |
Melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
title_sort |
melatonin as a therapeutic tool in ophtalmology : implication for glaucoma and uveitis |
publishDate |
2010 |
url |
https://repositorio.uca.edu.ar/handle/123456789/1666 |
work_keys_str_mv |
AT rosensteinruthe melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis AT pandiperumalseithikurippur melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis AT srinivasanvenkataramanujan melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis AT spencedavidwarren melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis AT browngregorym melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis AT cardinalidanielpedro melatoninasatherapeutictoolinophtalmologyimplicationforglaucomaanduveitis |
_version_ |
1756275068245114880 |