Meningeal carcinomatosis as the initial manifestation of lymphoma

Meningeal carcinomatosis as the initial manifestation of lymphoma

ABSTRACT Introduction: Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer. Case report: We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis. Discussion: LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.

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Main Authors: García-Aragonés,Laura, Montoya-Morcillo,Maria del Carmen, Donoso-Esteban,Irene, Broseta-Viana,Luis, Solís-García-del Pozo,Julián
Format: Digital revista
Language:English
Published: Research and Science S.L. 2022
Online Access:https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2022000400002
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spelling oai:scielo:S2529-850X20220004000022023-09-19Meningeal carcinomatosis as the initial manifestation of lymphomaGarcía-Aragonés,LauraMontoya-Morcillo,Maria del CarmenDonoso-Esteban,IreneBroseta-Viana,LuisSolís-García-del Pozo,Julián Leptomeningeal carcinomatosis type B lymphoma flow cytometry CSF cytology ABSTRACT Introduction: Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer. Case report: We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis. Discussion: LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.Research and Science S.L.Journal of Negative and No Positive Results v.7 n.4 20222022-12-01journal articletext/htmlhttps://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2022000400002en
institution SCIELO
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country España
countrycode ES
component Revista
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databasecode rev-scielo-es
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region Europa del Sur
libraryname SciELO
language English
format Digital
author García-Aragonés,Laura
Montoya-Morcillo,Maria del Carmen
Donoso-Esteban,Irene
Broseta-Viana,Luis
Solís-García-del Pozo,Julián
spellingShingle García-Aragonés,Laura
Montoya-Morcillo,Maria del Carmen
Donoso-Esteban,Irene
Broseta-Viana,Luis
Solís-García-del Pozo,Julián
Meningeal carcinomatosis as the initial manifestation of lymphoma
author_facet García-Aragonés,Laura
Montoya-Morcillo,Maria del Carmen
Donoso-Esteban,Irene
Broseta-Viana,Luis
Solís-García-del Pozo,Julián
author_sort García-Aragonés,Laura
title Meningeal carcinomatosis as the initial manifestation of lymphoma
title_short Meningeal carcinomatosis as the initial manifestation of lymphoma
title_full Meningeal carcinomatosis as the initial manifestation of lymphoma
title_fullStr Meningeal carcinomatosis as the initial manifestation of lymphoma
title_full_unstemmed Meningeal carcinomatosis as the initial manifestation of lymphoma
title_sort meningeal carcinomatosis as the initial manifestation of lymphoma
description ABSTRACT Introduction: Leptomeningeal carcinomatosis (LC) is diagnosed in 4-15% of cancer patients, and most cases (70%) are in the advanced phase of the disease. In only 5-10% of patients with LC, it is the initial manifestation of cancer. Case report: We present a case of a 46-year-old man with leptomeningeal carcinomatosis as the first manifestation of type B high-grade lymphoma. Cerebrospinal fluid (CSF) showed pleocytosis with a predominance of mononuclear cells, hyperproteinorrhachia, and glucose consumption. CSF cytology was negative for malignant cells in two samples. Magnetic resonance imaging and CSF flow cytometry gave the diagnosis. Discussion: LC is a diagnostic challenge. Differential diagnosis arises with infectious processes (tuberculosis) and autoimmune diseases. In cerebrospinal fluid, flow cytometry (FCM) has a higher sensitivity than cytology for the diagnosis of LC.
publisher Research and Science S.L.
publishDate 2022
url https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2529-850X2022000400002
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