Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland
ABSTRACT Objective: This study investigated whether ELABELA plays a role in the differential diagnosis of benign and malignant lesions of the thyroid gland. Subjects and methods: Of the 87 patients included in the study, 12 had undergone surgery for benign thyroid diseases, 30 had papillary thyroid cancer without invasion and/or lymph node metastasis in the surrounding tissues in the pathology report, and 45 had papillary thyroid cancer with invasion and/or lymph node metastasis in the surrounding tissues. Results: In the macrocarcinoma group, the proportion of patients with severe ELABELA staining (61.1%) was higher than that in the adenoma (50%) and microcarcinoma (23.8%) groups, while the proportion of those with mild to moderate staining was lower (p < 0.001). In the microcarcinoma group, the proportion of patients with severe staining was lower than that in the adenoma group, while the proportion of those with mild to moderate staining was higher (p < 0.001). In papillary thyroid carcinomas, the rates of moderate and severe staining in the classical variant, mild staining in the follicular variant, severe staining in the classical + follicular variant, and severe staining in the oncocytic variant were higher. Conclusion: To the best of our knowledge, this study is the first to be conducted on this subject. In this study, ELABELA was not found to be significant in the differential diagnosis of benign and malignant lesions of the thyroid gland. In papillary thyroid carcinomas, severe ELABELA staining patterns were more common in macrocarcinoma patients than in microcarcinoma patients.
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Sociedade Brasileira de Endocrinologia e Metabologia
2020
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oai:scielo:S2359-399720200006007722021-02-25Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid glandBankir,MehmetAbayli,CansuAcibucu,Fettah Apelin APJ thyroid toddler ABSTRACT Objective: This study investigated whether ELABELA plays a role in the differential diagnosis of benign and malignant lesions of the thyroid gland. Subjects and methods: Of the 87 patients included in the study, 12 had undergone surgery for benign thyroid diseases, 30 had papillary thyroid cancer without invasion and/or lymph node metastasis in the surrounding tissues in the pathology report, and 45 had papillary thyroid cancer with invasion and/or lymph node metastasis in the surrounding tissues. Results: In the macrocarcinoma group, the proportion of patients with severe ELABELA staining (61.1%) was higher than that in the adenoma (50%) and microcarcinoma (23.8%) groups, while the proportion of those with mild to moderate staining was lower (p < 0.001). In the microcarcinoma group, the proportion of patients with severe staining was lower than that in the adenoma group, while the proportion of those with mild to moderate staining was higher (p < 0.001). In papillary thyroid carcinomas, the rates of moderate and severe staining in the classical variant, mild staining in the follicular variant, severe staining in the classical + follicular variant, and severe staining in the oncocytic variant were higher. Conclusion: To the best of our knowledge, this study is the first to be conducted on this subject. In this study, ELABELA was not found to be significant in the differential diagnosis of benign and malignant lesions of the thyroid gland. In papillary thyroid carcinomas, severe ELABELA staining patterns were more common in macrocarcinoma patients than in microcarcinoma patients.info:eu-repo/semantics/openAccessSociedade Brasileira de Endocrinologia e MetabologiaArchives of Endocrinology and Metabolism v.64 n.6 20202020-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600772en10.20945/2359-3997000000293 |
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Bankir,Mehmet Abayli,Cansu Acibucu,Fettah |
| spellingShingle |
Bankir,Mehmet Abayli,Cansu Acibucu,Fettah Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| author_facet |
Bankir,Mehmet Abayli,Cansu Acibucu,Fettah |
| author_sort |
Bankir,Mehmet |
| title |
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| title_short |
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| title_full |
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| title_fullStr |
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| title_full_unstemmed |
Importance of ELABELA in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| title_sort |
importance of elabela in the differential diagnosis of benign and malignant lesions of the thyroid gland |
| description |
ABSTRACT Objective: This study investigated whether ELABELA plays a role in the differential diagnosis of benign and malignant lesions of the thyroid gland. Subjects and methods: Of the 87 patients included in the study, 12 had undergone surgery for benign thyroid diseases, 30 had papillary thyroid cancer without invasion and/or lymph node metastasis in the surrounding tissues in the pathology report, and 45 had papillary thyroid cancer with invasion and/or lymph node metastasis in the surrounding tissues. Results: In the macrocarcinoma group, the proportion of patients with severe ELABELA staining (61.1%) was higher than that in the adenoma (50%) and microcarcinoma (23.8%) groups, while the proportion of those with mild to moderate staining was lower (p < 0.001). In the microcarcinoma group, the proportion of patients with severe staining was lower than that in the adenoma group, while the proportion of those with mild to moderate staining was higher (p < 0.001). In papillary thyroid carcinomas, the rates of moderate and severe staining in the classical variant, mild staining in the follicular variant, severe staining in the classical + follicular variant, and severe staining in the oncocytic variant were higher. Conclusion: To the best of our knowledge, this study is the first to be conducted on this subject. In this study, ELABELA was not found to be significant in the differential diagnosis of benign and malignant lesions of the thyroid gland. In papillary thyroid carcinomas, severe ELABELA staining patterns were more common in macrocarcinoma patients than in microcarcinoma patients. |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000600772 |
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AT bankirmehmet importanceofelabelainthedifferentialdiagnosisofbenignandmalignantlesionsofthethyroidgland AT abaylicansu importanceofelabelainthedifferentialdiagnosisofbenignandmalignantlesionsofthethyroidgland AT acibucufettah importanceofelabelainthedifferentialdiagnosisofbenignandmalignantlesionsofthethyroidgland |
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