Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni
Abstract Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranhão. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranhão were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense.
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Colégio Brasileiro de Parasitologia Veterinária
2019
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oai:scielo:S1984-296120190004007692020-04-14Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoniSilva-Souza,Nêuton daSilva,Ana Patrícia de Carvalho daOliveira,Renata Mondego deLira,Maria Gabriela SampaioNogueira,Ranielly AraújoPenha-Silva,Tatiane Aranha daMelo,Solange de AraújoAndrade,Fábio Henrique Evangelista deSantos-Ribeiro,Larissa Sarmento dosCarvalho Neta,Alcina Vieira deAbreu-Silva,Ana Lucia Rodent schistosomiasis histopathology host Abstract Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranhão. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranhão were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense.info:eu-repo/semantics/openAccessColégio Brasileiro de Parasitologia VeterináriaRevista Brasileira de Parasitologia Veterinária v.28 n.4 20192019-12-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000400769en10.1590/s1984-29612019075 |
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Silva-Souza,Nêuton da Silva,Ana Patrícia de Carvalho da Oliveira,Renata Mondego de Lira,Maria Gabriela Sampaio Nogueira,Ranielly Araújo Penha-Silva,Tatiane Aranha da Melo,Solange de Araújo Andrade,Fábio Henrique Evangelista de Santos-Ribeiro,Larissa Sarmento dos Carvalho Neta,Alcina Vieira de Abreu-Silva,Ana Lucia |
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Silva-Souza,Nêuton da Silva,Ana Patrícia de Carvalho da Oliveira,Renata Mondego de Lira,Maria Gabriela Sampaio Nogueira,Ranielly Araújo Penha-Silva,Tatiane Aranha da Melo,Solange de Araújo Andrade,Fábio Henrique Evangelista de Santos-Ribeiro,Larissa Sarmento dos Carvalho Neta,Alcina Vieira de Abreu-Silva,Ana Lucia Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| author_facet |
Silva-Souza,Nêuton da Silva,Ana Patrícia de Carvalho da Oliveira,Renata Mondego de Lira,Maria Gabriela Sampaio Nogueira,Ranielly Araújo Penha-Silva,Tatiane Aranha da Melo,Solange de Araújo Andrade,Fábio Henrique Evangelista de Santos-Ribeiro,Larissa Sarmento dos Carvalho Neta,Alcina Vieira de Abreu-Silva,Ana Lucia |
| author_sort |
Silva-Souza,Nêuton da |
| title |
Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| title_short |
Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| title_full |
Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| title_fullStr |
Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| title_full_unstemmed |
Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni |
| title_sort |
parasitological and histological aspects of holochilus sciureus naturally infected by schistosoma mansoni |
| description |
Abstract Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranhão. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranhão were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense. |
| publisher |
Colégio Brasileiro de Parasitologia Veterinária |
| publishDate |
2019 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000400769 |
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