7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients

OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.

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Main Authors: Wang,Jia-Wei, Cong,Fei, Zhuo,Yan, Chen,Lin, Wang,Bo, Zhang,Yu-Qing
Format: Digital revista
Language:English
Published: Faculdade de Medicina / USP 2019
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221
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spelling oai:scielo:S1807-593220190001002212019-04-117.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patientsWang,Jia-WeiCong,FeiZhuo,YanChen,LinWang,BoZhang,Yu-Qing Parkinson’s Disease Pedunculopontine Nucleus 7.0T MRI Postural Instability Gait Disturbance OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.info:eu-repo/semantics/openAccessFaculdade de Medicina / USPClinics v.74 20192019-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221en10.6061/clinics/2019/e573
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
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author Wang,Jia-Wei
Cong,Fei
Zhuo,Yan
Chen,Lin
Wang,Bo
Zhang,Yu-Qing
spellingShingle Wang,Jia-Wei
Cong,Fei
Zhuo,Yan
Chen,Lin
Wang,Bo
Zhang,Yu-Qing
7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
author_facet Wang,Jia-Wei
Cong,Fei
Zhuo,Yan
Chen,Lin
Wang,Bo
Zhang,Yu-Qing
author_sort Wang,Jia-Wei
title 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
title_short 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
title_full 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
title_fullStr 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
title_full_unstemmed 7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson’s disease patients
title_sort 7.0t ultrahigh-field mri directly visualized the pedunculopontine nucleus in parkinson’s disease patients
description OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson’s disease (PD) patients with postural instability and gait disturbance that is refractory to other treatment modalities. However, the PPN is typically difficult to visualize with magnetic resonance imaging (MRI) at clinical field strengths, which greatly limits the PPN as a viable surgical target for deep brain stimulation (DBS). Thus, the aim of this study is to directly visualize the PPN based on 7.0T ultrahigh-field MRI. METHODS: Five PD patients were enrolled and scanned using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI scanner. Then, the MP2RAGE sequences were imported into a commercially available navigation system. The coordinates of the directly localized PPN poles were recorded in the navigation system relative to the anterior commissure-posterior commissure plane. RESULTS: Our results indicated that the PPN presented intermediate signal intensity in the 7.0T ultrahigh-field MR images in comparison with the surrounding structure, such as the hypo-intensity of the periaqueductal gray and the hyperintensity of the neighboring white matter tracts, in PD patients. The mean coordinates for the rostral and caudal poles of PPN were 6.50 mm and 7.20 mm lateral, 1.58 mm and 2.21 mm posterior, and 8.89 mm and 13.83 mm relative to the posterior commissure. CONCLUSION: Our findings provide, for the first time, direct visualization of the PPN using the MP2RAGE sequence on a 7.0T ultrahigh-field MRI, which may improve the accuracy of stereotactic targeting of the PPN and improve the outcomes in patients undergoing DBS.
publisher Faculdade de Medicina / USP
publishDate 2019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322019000100221
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