Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment
ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.
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Sociedade Brasileira de Pneumologia e Tisiologia
2019
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oai:scielo:S1806-371320190005002062019-09-13Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatmentGross,Jefferson LuizVega,Marcel Adalid TapiaFrenhi,Guilherme StrambiTorres,Silvio MeloCampos,Antonio Hugo José Froes MarquesPinto,Clovis Antonio LopesCosta,Felipe D’AlmeidaHaddad,Fabio José Carcinoid tumor/diagnosis Carcinoid tumor/surgery Neoplasms, second primary Lung neoplasms ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.info:eu-repo/semantics/openAccessSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia v.45 n.5 20192019-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206en10.1590/1806-3713/e20180140 |
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Gross,Jefferson Luiz Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José |
| spellingShingle |
Gross,Jefferson Luiz Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| author_facet |
Gross,Jefferson Luiz Vega,Marcel Adalid Tapia Frenhi,Guilherme Strambi Torres,Silvio Melo Campos,Antonio Hugo José Froes Marques Pinto,Clovis Antonio Lopes Costa,Felipe D’Almeida Haddad,Fabio José |
| author_sort |
Gross,Jefferson Luiz |
| title |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| title_short |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| title_full |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| title_fullStr |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| title_full_unstemmed |
Bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| title_sort |
bronchial carcinoid tumors: second primary neoplasms and outcomes of surgical treatment |
| description |
ABSTRACT Objective: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. Methods: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. Results: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. Conclusions: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms. |
| publisher |
Sociedade Brasileira de Pneumologia e Tisiologia |
| publishDate |
2019 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000500206 |
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