The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.
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Sociedade Brasileira de Urologia
2011
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oai:scielo:S1677-553820110003000022011-07-27The role of the cell adhesion molecules (integrins / cadherins) in prostate cancerDrivalos,AlexandrosPapatsoris,Athanasios G.Chrisofos,MichaelEfstathiou,EleniDimopoulos,Meletios A. cadherins integrins prostate cancer review During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation.info:eu-repo/semantics/openAccessSociedade Brasileira de UrologiaInternational braz j urol v.37 n.3 20112011-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000300002en10.1590/S1677-55382011000300002 |
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Drivalos,Alexandros Papatsoris,Athanasios G. Chrisofos,Michael Efstathiou,Eleni Dimopoulos,Meletios A. |
| spellingShingle |
Drivalos,Alexandros Papatsoris,Athanasios G. Chrisofos,Michael Efstathiou,Eleni Dimopoulos,Meletios A. The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| author_facet |
Drivalos,Alexandros Papatsoris,Athanasios G. Chrisofos,Michael Efstathiou,Eleni Dimopoulos,Meletios A. |
| author_sort |
Drivalos,Alexandros |
| title |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| title_short |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| title_full |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| title_fullStr |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| title_full_unstemmed |
The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| title_sort |
role of the cell adhesion molecules (integrins / cadherins) in prostate cancer |
| description |
During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation. |
| publisher |
Sociedade Brasileira de Urologia |
| publishDate |
2011 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382011000300002 |
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