Transdermal drug delivery treatment for overactive bladder

Overactive bladder is commonly treated with oral anticholinergic drugs such as oxybutynin chloride. Although oral anticholinergic agents have been effective in controlling urinary urgency and incontinence, adverse events, particularly dry mouth, often cause patients to discontinue oral therapy and to endure incontinence. Oxybutynin can be delivered transcutaneously, maintaining the efficacy of oral oxybutynin while significantly minimizing side effects (e.g., dry mouth) that may complicate therapy. By avoiding hepatic and gastrointestinal metabolism of oxybutynin, less N-desethyloxybutynin (N-DEO) is produced and this compound is deemed to be responsible for anticholinergic side effects such as dry mouth. This novel oxybutynin formulation offers patients with OAB and urge urinary incontinence a well-tolerated option for managing the symptoms of overactive bladder.

Bibliographic Details

Main Authors:	Dmochowski,Roger R., Starkman,Jonathan S., Davila,G. Willy
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Urologia 2006
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382006000500003
Tags:	Add Tag No Tags, Be the first to tag this record!