Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions
ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.
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Sociedade Brasileira de Patologia Clínica
2020
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oai:scielo:S1676-244420200001006002020-05-06Evaluation of HLA-G immune checkpoint molecule in melanocytic lesionsGomes,Raylane PCaetano,Gabriela TayrineSampaio,Lucas Henrique FSilva,Camila RCosta,Maurício BCysneiro,Maria AuxiliadoraWastowski,Isabela Jubé melanoma HLA-G antigens immunohistochemistry ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis.info:eu-repo/semantics/openAccessSociedade Brasileira de Patologia Clínica Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 20202020-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600en10.5935/1676-2444.20200016 |
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| author |
Gomes,Raylane P Caetano,Gabriela Tayrine Sampaio,Lucas Henrique F Silva,Camila R Costa,Maurício B Cysneiro,Maria Auxiliadora Wastowski,Isabela Jubé |
| spellingShingle |
Gomes,Raylane P Caetano,Gabriela Tayrine Sampaio,Lucas Henrique F Silva,Camila R Costa,Maurício B Cysneiro,Maria Auxiliadora Wastowski,Isabela Jubé Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| author_facet |
Gomes,Raylane P Caetano,Gabriela Tayrine Sampaio,Lucas Henrique F Silva,Camila R Costa,Maurício B Cysneiro,Maria Auxiliadora Wastowski,Isabela Jubé |
| author_sort |
Gomes,Raylane P |
| title |
Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_short |
Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_full |
Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_fullStr |
Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_full_unstemmed |
Evaluation of HLA-G immune checkpoint molecule in melanocytic lesions |
| title_sort |
evaluation of hla-g immune checkpoint molecule in melanocytic lesions |
| description |
ABSTRACT The human leukocyte antigen-G (HLA-G) is a non-classical molecule of the major histocompatibility complex. HLA-G has been associated with the process of tumorigenesis and tumor escape. In this study, we aim to evaluate the HLA-G expression in melanocytic lesions and in melanoma for determining when melanocytic lesions start its expression. Twenty-two skin biopsies samples were submitted to immunohistochemistry; HLA-G expression was detected in 63.6% of the samples. This expression in melanocytic cells was significantly higher in melanoma than in benign melanocytic lesions (p < 0.002). Our results suggest that HLA-G expression starts late in the process of tumorigenesis. |
| publisher |
Sociedade Brasileira de Patologia Clínica |
| publishDate |
2020 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100600 |
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