The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer

The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer

INTRODUCTION: Prostate cancer has high prevalence and mortality among men. Some of the findings on prostate biopsy may be related to the prognosis of the disease. OBJECTIVE: To evaluate the association between the percentage of fragments affected by cancer in the prostate biopsy and the pathological staging in the surgical specimen. MATERIALS AND METHODS: Selected 159 patients underwent radical prostatectomy (RP) between 2003 and 2009. Data was collected on age, digital rectal exam, prostate-specific antigen (PSA), Gleason score, number of biopsy fragments, number of fragments affected by tumor, and tumor extension in the surgical specimen. Statistical analysis with Student's t-test, chi-squared test, and multiple logistic regression evaluated the association of percentage of affected fragments (PAF) with tumor extension and its predictive value. RESULTS: The patients mean age and PSA were respectively 64 years and 8.5 ng/ml. Histopathologic evaluation of surgical specimens revealed 20.8% of patients with extraprostatic disease, 8.2% with seminal vesicle invasion and 35.8% with positive margins. We found that patients with extraprostatic disease, positive surgical margins, and seminal vesicle invasion had a higher mean PAF. PAF was divided into three groups: less than 34%, 34% to 50%, and greater than 50%, and the higher the PFA, the larger the increase in pathological changes. CONCLUSION: PAF in biopsy is a simple and practical parameter, which should be used as a predictor of pathological stage in RP specimen.

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Main Authors: Andrade,Rógerson Tenorio de, Lucena,Roberto Gonçalves de, Braga,Catarina de Moraes, Silva,Vilma Maria da, Santos Jr,Misael Wanderley, Pontes Filho,Nicodemos Teles de
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Patologia Clínica 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000500009
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spelling oai:scielo:S1676-244420130005000092013-12-12The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancerAndrade,Rógerson Tenorio deLucena,Roberto Gonçalves deBraga,Catarina de MoraesSilva,Vilma Maria daSantos Jr,Misael WanderleyPontes Filho,Nicodemos Teles de prostatic neoplasm needle biopsy pathology neoplasm staging INTRODUCTION: Prostate cancer has high prevalence and mortality among men. Some of the findings on prostate biopsy may be related to the prognosis of the disease. OBJECTIVE: To evaluate the association between the percentage of fragments affected by cancer in the prostate biopsy and the pathological staging in the surgical specimen. MATERIALS AND METHODS: Selected 159 patients underwent radical prostatectomy (RP) between 2003 and 2009. Data was collected on age, digital rectal exam, prostate-specific antigen (PSA), Gleason score, number of biopsy fragments, number of fragments affected by tumor, and tumor extension in the surgical specimen. Statistical analysis with Student's t-test, chi-squared test, and multiple logistic regression evaluated the association of percentage of affected fragments (PAF) with tumor extension and its predictive value. RESULTS: The patients mean age and PSA were respectively 64 years and 8.5 ng/ml. Histopathologic evaluation of surgical specimens revealed 20.8% of patients with extraprostatic disease, 8.2% with seminal vesicle invasion and 35.8% with positive margins. We found that patients with extraprostatic disease, positive surgical margins, and seminal vesicle invasion had a higher mean PAF. PAF was divided into three groups: less than 34%, 34% to 50%, and greater than 50%, and the higher the PFA, the larger the increase in pathological changes. CONCLUSION: PAF in biopsy is a simple and practical parameter, which should be used as a predictor of pathological stage in RP specimen.info:eu-repo/semantics/openAccessSociedade Brasileira de Patologia Clínica Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.5 20132013-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000500009en10.1590/S1676-24442013000500009
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databasecode rev-scielo-br
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libraryname SciELO
language English
format Digital
author Andrade,Rógerson Tenorio de
Lucena,Roberto Gonçalves de
Braga,Catarina de Moraes
Silva,Vilma Maria da
Santos Jr,Misael Wanderley
Pontes Filho,Nicodemos Teles de
spellingShingle Andrade,Rógerson Tenorio de
Lucena,Roberto Gonçalves de
Braga,Catarina de Moraes
Silva,Vilma Maria da
Santos Jr,Misael Wanderley
Pontes Filho,Nicodemos Teles de
The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
author_facet Andrade,Rógerson Tenorio de
Lucena,Roberto Gonçalves de
Braga,Catarina de Moraes
Silva,Vilma Maria da
Santos Jr,Misael Wanderley
Pontes Filho,Nicodemos Teles de
author_sort Andrade,Rógerson Tenorio de
title The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
title_short The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
title_full The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
title_fullStr The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
title_full_unstemmed The percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
title_sort percentage of affected fragments in needle biopsy in the assessment of pathological staging of prostate cancer
description INTRODUCTION: Prostate cancer has high prevalence and mortality among men. Some of the findings on prostate biopsy may be related to the prognosis of the disease. OBJECTIVE: To evaluate the association between the percentage of fragments affected by cancer in the prostate biopsy and the pathological staging in the surgical specimen. MATERIALS AND METHODS: Selected 159 patients underwent radical prostatectomy (RP) between 2003 and 2009. Data was collected on age, digital rectal exam, prostate-specific antigen (PSA), Gleason score, number of biopsy fragments, number of fragments affected by tumor, and tumor extension in the surgical specimen. Statistical analysis with Student's t-test, chi-squared test, and multiple logistic regression evaluated the association of percentage of affected fragments (PAF) with tumor extension and its predictive value. RESULTS: The patients mean age and PSA were respectively 64 years and 8.5 ng/ml. Histopathologic evaluation of surgical specimens revealed 20.8% of patients with extraprostatic disease, 8.2% with seminal vesicle invasion and 35.8% with positive margins. We found that patients with extraprostatic disease, positive surgical margins, and seminal vesicle invasion had a higher mean PAF. PAF was divided into three groups: less than 34%, 34% to 50%, and greater than 50%, and the higher the PFA, the larger the increase in pathological changes. CONCLUSION: PAF in biopsy is a simple and practical parameter, which should be used as a predictor of pathological stage in RP specimen.
publisher Sociedade Brasileira de Patologia Clínica
publishDate 2013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000500009
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