Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain
Objective: To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry. Method: Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex. Results: Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain. Conclusions: Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD.
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Associação Brasileira de Psiquiatria
2013
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oai:scielo:S1516-444620130004003802014-09-26Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brainValvassori,Samira S.Bavaresco,Daniela V.Scaini,GiselliVarela,Roger B.Streck,Emilio L.Chagas,Marcos H.Hallak,Jaime E.C.Zuardi,Antonio W.Crippa,José A.Quevedo,João Cannabidiol mitochondrial respiratory chain creatine kinase Objective: To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry. Method: Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex. Results: Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain. Conclusions: Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD. info:eu-repo/semantics/openAccessAssociação Brasileira de PsiquiatriaBrazilian Journal of Psychiatry v.35 n.4 20132013-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000400380en10.1590/1516-4446-2012-0886 |
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Valvassori,Samira S. Bavaresco,Daniela V. Scaini,Giselli Varela,Roger B. Streck,Emilio L. Chagas,Marcos H. Hallak,Jaime E.C. Zuardi,Antonio W. Crippa,José A. Quevedo,João |
| spellingShingle |
Valvassori,Samira S. Bavaresco,Daniela V. Scaini,Giselli Varela,Roger B. Streck,Emilio L. Chagas,Marcos H. Hallak,Jaime E.C. Zuardi,Antonio W. Crippa,José A. Quevedo,João Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| author_facet |
Valvassori,Samira S. Bavaresco,Daniela V. Scaini,Giselli Varela,Roger B. Streck,Emilio L. Chagas,Marcos H. Hallak,Jaime E.C. Zuardi,Antonio W. Crippa,José A. Quevedo,João |
| author_sort |
Valvassori,Samira S. |
| title |
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| title_short |
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| title_full |
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| title_fullStr |
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| title_full_unstemmed |
Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| title_sort |
acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain |
| description |
Objective: To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry. Method: Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex. Results: Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain. Conclusions: Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD. |
| publisher |
Associação Brasileira de Psiquiatria |
| publishDate |
2013 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000400380 |
| work_keys_str_mv |
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| _version_ |
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