The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia

ABSTRACT: CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients.

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Main Authors: Argani,Hassan, Ghorbanihaghjo,Amir, Vatankhahan,Hamid, Rashtchizadeh,Nadereh, Raeisi,Sina, Ilghami,Hadi
Format: Digital revista
Language:English
Published: Associação Paulista de Medicina - APM 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300234
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spelling oai:scielo:S1516-318020160003002342016-06-24The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemiaArgani,HassanGhorbanihaghjo,AmirVatankhahan,HamidRashtchizadeh,NaderehRaeisi,SinaIlghami,Hadi Cholesterol, HDL Apolipoprotein A-I Flavonoids Cholesterol, LDL Cholesterol ABSTRACT: CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.134 n.3 20162016-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300234en10.1590/1516-3180.2015.01702312
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countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Argani,Hassan
Ghorbanihaghjo,Amir
Vatankhahan,Hamid
Rashtchizadeh,Nadereh
Raeisi,Sina
Ilghami,Hadi
spellingShingle Argani,Hassan
Ghorbanihaghjo,Amir
Vatankhahan,Hamid
Rashtchizadeh,Nadereh
Raeisi,Sina
Ilghami,Hadi
The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
author_facet Argani,Hassan
Ghorbanihaghjo,Amir
Vatankhahan,Hamid
Rashtchizadeh,Nadereh
Raeisi,Sina
Ilghami,Hadi
author_sort Argani,Hassan
title The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
title_short The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
title_full The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
title_fullStr The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
title_full_unstemmed The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
title_sort effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia
description ABSTRACT: CONTEXT AND OBJECTIVE: Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS: A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks. RESULTS: Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen. CONCLUSION: It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients.
publisher Associação Paulista de Medicina - APM
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300234
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