Pituitary macroadenoma presenting as a nasal tumor: case report
CONTEXT: Pituitary macroadenomas are rare intracranial tumors. In a few cases, they may present aggressive behavior and invade the sphenoid sinus and nasal cavity, causing unusual symptoms. In this paper, we report an atypical case of pituitary adenoma presenting as a nasal mass.CASE REPORT: The patient was a 44-year-old woman who had had amenorrhea and galactorrhea for ten months, with associated nasal obstruction, macroglossia and acromegaly. Both growth hormone and prolactin levels were increased. Magnetic resonance imaging showed a large mass originating from the lower surface of the pituitary gland, associated with sella turcica erosion and tumor extension through the sphenoid sinus and nasal cavity. Histopathological analysis demonstrated a chromophobe pituitary adenoma with densely packed rounded epithelial cells, with some atypias and rare mitotic figures. There was no evidence of metastases.CONCLUSION: Macroadenoma invading the nasal cavity is a rare condition and few similar cases have been reported in the literature. This study contributes towards showing that tumor extension to the sphenoid sinus and nasopharynx needs to be considered and investigated in order to make an early diagnosis when atypical symptoms like nasal obstruction are present.
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Associação Paulista de Medicina - APM
2014
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oai:scielo:S1516-318020140006003772015-09-29Pituitary macroadenoma presenting as a nasal tumor: case reportSilva Junior,Nivaldo AdolfoReis,FabianoMiura,Larissa KaoriVieira,Guilherme HenriqueQueiroz,Luciano SouzaGarmes,Heraldo MendesBenetti-Pinto,Cristina Laguna Pituitary neoplasms. Nasal cavity Growth hormone-secreting pituitary adenoma Amenorrhea Prolactin CONTEXT: Pituitary macroadenomas are rare intracranial tumors. In a few cases, they may present aggressive behavior and invade the sphenoid sinus and nasal cavity, causing unusual symptoms. In this paper, we report an atypical case of pituitary adenoma presenting as a nasal mass.CASE REPORT: The patient was a 44-year-old woman who had had amenorrhea and galactorrhea for ten months, with associated nasal obstruction, macroglossia and acromegaly. Both growth hormone and prolactin levels were increased. Magnetic resonance imaging showed a large mass originating from the lower surface of the pituitary gland, associated with sella turcica erosion and tumor extension through the sphenoid sinus and nasal cavity. Histopathological analysis demonstrated a chromophobe pituitary adenoma with densely packed rounded epithelial cells, with some atypias and rare mitotic figures. There was no evidence of metastases.CONCLUSION: Macroadenoma invading the nasal cavity is a rare condition and few similar cases have been reported in the literature. This study contributes towards showing that tumor extension to the sphenoid sinus and nasopharynx needs to be considered and investigated in order to make an early diagnosis when atypical symptoms like nasal obstruction are present.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.132 n.6 20142014-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600377en10.1590/1516-3180-2014-1326693 |
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Silva Junior,Nivaldo Adolfo Reis,Fabiano Miura,Larissa Kaori Vieira,Guilherme Henrique Queiroz,Luciano Souza Garmes,Heraldo Mendes Benetti-Pinto,Cristina Laguna |
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Silva Junior,Nivaldo Adolfo Reis,Fabiano Miura,Larissa Kaori Vieira,Guilherme Henrique Queiroz,Luciano Souza Garmes,Heraldo Mendes Benetti-Pinto,Cristina Laguna Pituitary macroadenoma presenting as a nasal tumor: case report |
author_facet |
Silva Junior,Nivaldo Adolfo Reis,Fabiano Miura,Larissa Kaori Vieira,Guilherme Henrique Queiroz,Luciano Souza Garmes,Heraldo Mendes Benetti-Pinto,Cristina Laguna |
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Silva Junior,Nivaldo Adolfo |
title |
Pituitary macroadenoma presenting as a nasal tumor: case report |
title_short |
Pituitary macroadenoma presenting as a nasal tumor: case report |
title_full |
Pituitary macroadenoma presenting as a nasal tumor: case report |
title_fullStr |
Pituitary macroadenoma presenting as a nasal tumor: case report |
title_full_unstemmed |
Pituitary macroadenoma presenting as a nasal tumor: case report |
title_sort |
pituitary macroadenoma presenting as a nasal tumor: case report |
description |
CONTEXT: Pituitary macroadenomas are rare intracranial tumors. In a few cases, they may present aggressive behavior and invade the sphenoid sinus and nasal cavity, causing unusual symptoms. In this paper, we report an atypical case of pituitary adenoma presenting as a nasal mass.CASE REPORT: The patient was a 44-year-old woman who had had amenorrhea and galactorrhea for ten months, with associated nasal obstruction, macroglossia and acromegaly. Both growth hormone and prolactin levels were increased. Magnetic resonance imaging showed a large mass originating from the lower surface of the pituitary gland, associated with sella turcica erosion and tumor extension through the sphenoid sinus and nasal cavity. Histopathological analysis demonstrated a chromophobe pituitary adenoma with densely packed rounded epithelial cells, with some atypias and rare mitotic figures. There was no evidence of metastases.CONCLUSION: Macroadenoma invading the nasal cavity is a rare condition and few similar cases have been reported in the literature. This study contributes towards showing that tumor extension to the sphenoid sinus and nasopharynx needs to be considered and investigated in order to make an early diagnosis when atypical symptoms like nasal obstruction are present. |
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Associação Paulista de Medicina - APM |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802014000600377 |
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