Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples
Febuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedade Portuguesa de Electroquímica
2016
|
| Online Access: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0872-19042016000500004 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0872-190420160005000042016-11-10Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma SamplesHabib,I. H. I.Rizk,M. S.El-Alamin,M. M. AbouImam,G. S. Febuxostat differential pulse voltammetry HMDE pharmaceutical and plasma samples Febuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique.info:eu-repo/semantics/openAccessSociedade Portuguesa de ElectroquímicaPortugaliae Electrochimica Acta v.34 n.5 20162016-09-01info:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004en10.4152/pea.201605343 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Portugal |
| countrycode |
PT |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-pt |
| tag |
revista |
| region |
Europa del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Habib,I. H. I. Rizk,M. S. El-Alamin,M. M. Abou Imam,G. S. |
| spellingShingle |
Habib,I. H. I. Rizk,M. S. El-Alamin,M. M. Abou Imam,G. S. Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| author_facet |
Habib,I. H. I. Rizk,M. S. El-Alamin,M. M. Abou Imam,G. S. |
| author_sort |
Habib,I. H. I. |
| title |
Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| title_short |
Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| title_full |
Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| title_fullStr |
Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| title_full_unstemmed |
Cathodic Stripping Voltammetric Determination of Febuxostat in Pharmaceutical Dosage Form and Plasma Samples |
| title_sort |
cathodic stripping voltammetric determination of febuxostat in pharmaceutical dosage form and plasma samples |
| description |
Febuxostat FEB was determined by differential pulse ''DP'' adsorptive stripping voltammetry and hanging mercury drop electrode. In 0.04 mol L-1 Britton-Robinson buffer solution, pH 10, an irreversible electrochemical reaction took place at about -350 mV, and the peak current was linearly varied over the concentration range of 12.5-200 ng mL-1 FEB, with correlation coefficients of 0.9995, after 60 s accumulation time, stirring at a speed of 600 rpm, rest for 10 s, then cathodic stripping sweep from -100 to 600 mV, with a scan rate of 60 mV/s. The limits of detection and quantization were 6.93, 23.09 ng mL-1. The method was applicable for determining FEB in pharmaceutical tablets and in spiked plasma. The results of the proposed method were compared with that obtained by the UV-spectrophotometric technique. |
| publisher |
Sociedade Portuguesa de Electroquímica |
| publishDate |
2016 |
| url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042016000500004 |
| work_keys_str_mv |
AT habibihi cathodicstrippingvoltammetricdeterminationoffebuxostatinpharmaceuticaldosageformandplasmasamples AT rizkms cathodicstrippingvoltammetricdeterminationoffebuxostatinpharmaceuticaldosageformandplasmasamples AT elalaminmmabou cathodicstrippingvoltammetricdeterminationoffebuxostatinpharmaceuticaldosageformandplasmasamples AT imamgs cathodicstrippingvoltammetricdeterminationoffebuxostatinpharmaceuticaldosageformandplasmasamples |
| _version_ |
1756001904963354624 |