The antifungal effect of six commercial extracts of Chilean propolis on Candida spp

Propolis has been used in traditional medicine for many centuries because of its benefcial health properties, including its antimicrobial capacity. Prosthesis stomatitis affects a signifcant percentage of users of removable dentures; Candida albicans is the most common fungal species associated with the development of this pathology. Thus, the objectives of this study were: a. To evaluate the antifungal activity of six commercial propolis extracts against Candida spp. that was isolated from the oral cavity of removable dentures users, and b. To determine chemical characteristics of the propolis extracts evaluated. Among the results, we note that these concentrations of polyphenols varied between 9 ± 0.3 and 85 ± 2.1 mg mL-1. Chromatographic analysis was able to detect 35 compounds, among which were caffeic acid, myricetin, quercetin, kaempferol, apigenin, pinocembrin, galangin, and caffeic acid phenyl ester (CAPE). All strains tested were inhibited by the liquid extracts of propolis. The MID ranged between 1:40 and 1:1280, and the MIC for C. albicans ranged from 197 µg mL-1 to 441 µg mL-1. From the results obtained in this investigation, we can conclude that all propolis extracts evaluated are capable of inhibiting the development of Candida spp. However, they show signifcant differences in the concentration of polyphenols present and in antifungal activity.

Bibliographic Details

Main Authors:	Herrera,Christian L, Alvear,Marysol, Barrientos,Leticia, Montenegro,Gloria, Salazar,Luis A
Format:	Digital revista
Language:	English
Published:	Pontificia Universidad Católica de Chile. Facultad de Agronomía e Ingeniería Forestal 2010
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202010000100007
Tags:	Add Tag No Tags, Be the first to tag this record!