SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS
Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).
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Sociedad Chilena de Química
2010
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oai:scielo:S0717-970720100002000162010-09-06SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLSESPINOZA CATALÁN,LUISMADRID VILLEGAS,ALEJANDROTABORGA LIBER,LAUTAROVILLENA GARCÍA,JOANCUELLAR FRITIS,MAURICIOCARRASCO ALTAMIRANO,HÉCTOR Antiproliferative activity safrole derivatives synthesis Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016en10.4067/S0717-97072010000200016 |
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ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR |
| spellingShingle |
ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| author_facet |
ESPINOZA CATALÁN,LUIS MADRID VILLEGAS,ALEJANDRO TABORGA LIBER,LAUTARO VILLENA GARCÍA,JOAN CUELLAR FRITIS,MAURICIO CARRASCO ALTAMIRANO,HÉCTOR |
| author_sort |
ESPINOZA CATALÁN,LUIS |
| title |
SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| title_short |
SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| title_full |
SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| title_fullStr |
SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| title_full_unstemmed |
SYNTHESIS OF NINE SAFROLE DERIVATIVES AND THEIR ANTIPROLIFERATIVE ACTIVITY TOWARDS HUMAN CANCER CELLS |
| title_sort |
synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells |
| description |
Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells). |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000200016 |
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