Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.

Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.

Abstract This is the first report for Venezuela of virulence/pathogenicity and resistance factors in intrahospital (HCAI) and community-acquired infections (CAI) by P. mirabilis in two main hospitals from Eastern Venezuela. Virulence factors such as motility, biofilms, and resistance to serum killing (RSK) were determined. Antimicrobial susceptibility allowed classifying the isolates into resistant, multidrug resistant (MDR) and extensively drug-resistant (XDR). P. mirabilis was identified in HCAI in both hospitals mostly from secretions, while some CAI were identified from urine and secretions. Twitching, swarming, biofilm and RSK were identified in many isolates. Eleven antimicrobials showed resistance frequencies from 22-54% in one or both hospitals. A high frequency of MDR isolates was found in these hospitals (60.6 to 56.5%). Strains carrying both bla CTX-M and bla TEM genes were found in one hospital in a frequency of 27.0%. We also found that the frequency of MDR was lower in strains with three or more virulence factors compared to those with fewer factors. Bacteria with swarming showed 5.85 times lower probability of being MDR, and those with twitching, 7.52 times lower probability. Infections by MDR/XDR P. mirabilis strains in HCAI and CAI represent a public health problem that requires effective control and prevention measures to reduce their potential spread and persistence in the population.

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Main Authors: Rodulfo,Hectorina, Horta,Milagro, Mata,Genova, Gutiérrez,Rafela, González,Yarmilia, Michelli,Elvia, Guzman,Militza, Martínez,Dianny, Sharma,Ashutosh, De Donato,Marcos
Format: Digital revista
Language:English
Published: Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia 2021
Online Access:http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332021000100037
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spelling oai:scielo:S0535-513320210001000372022-11-08Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.Rodulfo,HectorinaHorta,MilagroMata,GenovaGutiérrez,RafelaGonzález,YarmiliaMichelli,ElviaGuzman,MilitzaMartínez,DiannySharma,AshutoshDe Donato,Marcos Proteus MDR virulence resistance antimicrobials Abstract This is the first report for Venezuela of virulence/pathogenicity and resistance factors in intrahospital (HCAI) and community-acquired infections (CAI) by P. mirabilis in two main hospitals from Eastern Venezuela. Virulence factors such as motility, biofilms, and resistance to serum killing (RSK) were determined. Antimicrobial susceptibility allowed classifying the isolates into resistant, multidrug resistant (MDR) and extensively drug-resistant (XDR). P. mirabilis was identified in HCAI in both hospitals mostly from secretions, while some CAI were identified from urine and secretions. Twitching, swarming, biofilm and RSK were identified in many isolates. Eleven antimicrobials showed resistance frequencies from 22-54% in one or both hospitals. A high frequency of MDR isolates was found in these hospitals (60.6 to 56.5%). Strains carrying both bla CTX-M and bla TEM genes were found in one hospital in a frequency of 27.0%. We also found that the frequency of MDR was lower in strains with three or more virulence factors compared to those with fewer factors. Bacteria with swarming showed 5.85 times lower probability of being MDR, and those with twitching, 7.52 times lower probability. Infections by MDR/XDR P. mirabilis strains in HCAI and CAI represent a public health problem that requires effective control and prevention measures to reduce their potential spread and persistence in the population.info:eu-repo/semantics/openAccessInstituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del ZuliaInvestigación Clínica v.62 n.1 20212021-03-01info:eu-repo/semantics/articletext/htmlhttp://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332021000100037en10.22209/ic.v62n1a04
institution SCIELO
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country Venezuela
countrycode VE
component Revista
access En linea
databasecode rev-scielo-ve
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region America del Sur
libraryname SciELO
language English
format Digital
author Rodulfo,Hectorina
Horta,Milagro
Mata,Genova
Gutiérrez,Rafela
González,Yarmilia
Michelli,Elvia
Guzman,Militza
Martínez,Dianny
Sharma,Ashutosh
De Donato,Marcos
spellingShingle Rodulfo,Hectorina
Horta,Milagro
Mata,Genova
Gutiérrez,Rafela
González,Yarmilia
Michelli,Elvia
Guzman,Militza
Martínez,Dianny
Sharma,Ashutosh
De Donato,Marcos
Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
author_facet Rodulfo,Hectorina
Horta,Milagro
Mata,Genova
Gutiérrez,Rafela
González,Yarmilia
Michelli,Elvia
Guzman,Militza
Martínez,Dianny
Sharma,Ashutosh
De Donato,Marcos
author_sort Rodulfo,Hectorina
title Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
title_short Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
title_full Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
title_fullStr Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
title_full_unstemmed Negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by Proteus mirabilis, in Eastern Venezuela.
title_sort negative correlation between virulence and multidrug resistance in intrahospital and community acquired infections by proteus mirabilis, in eastern venezuela.
description Abstract This is the first report for Venezuela of virulence/pathogenicity and resistance factors in intrahospital (HCAI) and community-acquired infections (CAI) by P. mirabilis in two main hospitals from Eastern Venezuela. Virulence factors such as motility, biofilms, and resistance to serum killing (RSK) were determined. Antimicrobial susceptibility allowed classifying the isolates into resistant, multidrug resistant (MDR) and extensively drug-resistant (XDR). P. mirabilis was identified in HCAI in both hospitals mostly from secretions, while some CAI were identified from urine and secretions. Twitching, swarming, biofilm and RSK were identified in many isolates. Eleven antimicrobials showed resistance frequencies from 22-54% in one or both hospitals. A high frequency of MDR isolates was found in these hospitals (60.6 to 56.5%). Strains carrying both bla CTX-M and bla TEM genes were found in one hospital in a frequency of 27.0%. We also found that the frequency of MDR was lower in strains with three or more virulence factors compared to those with fewer factors. Bacteria with swarming showed 5.85 times lower probability of being MDR, and those with twitching, 7.52 times lower probability. Infections by MDR/XDR P. mirabilis strains in HCAI and CAI represent a public health problem that requires effective control and prevention measures to reduce their potential spread and persistence in the population.
publisher Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia
publishDate 2021
url http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332021000100037
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