Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers

Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers

The aim of the present research was to prepare and evaluate a gastroretentive drug delivery system for metformin HCl, using synthetic and semi-synthetic polymers. The floating approach was applied for preparing gastroretentive tablets (GRT) and these tablets were manufactured by the direct compression method. The drug delivery system comprises of synthetic and semi-synthetic polymers such as polyethylene oxide and Carboxymethyl ethyl cellulose (CMEC) as release-retarding polymers. GRT were evaluated for physico-chemical properties like weight variation, hardness, assay friability, in vitro floating behaviour, swelling studies, in vitro dissolution studies and rate order kinetics. Based upon the drug release and floating properties, two formulations (MP04 & MC03) were selected as optimized formulations. The optimized formulations MP04 and MC03 followed zero order rate kinetics, with non-Fickian diffusion and first order rate kinetics with erosion mechanism, respectively. The optimized formulation was characterised with FTIR studies and it was observed that there was no interaction between the drug and polymers.

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Main Authors: Srikanth Meka,Venkata, Gorajana,Adinarayana, Rajan Dharmanlingam,Senthil, Murthy Kolapalli,Venkata Ramana
Format: Digital revista
Language:English
Published: Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia 2013
Online Access:http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332013000400002
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spelling oai:scielo:S0535-513320130004000022015-02-14Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymersSrikanth Meka,VenkataGorajana,AdinarayanaRajan Dharmanlingam,SenthilMurthy Kolapalli,Venkata Ramana gastroretentive floating carboxymethyl ethyl cellulose in vitro dissolution polyethylene oxide metformin HCl The aim of the present research was to prepare and evaluate a gastroretentive drug delivery system for metformin HCl, using synthetic and semi-synthetic polymers. The floating approach was applied for preparing gastroretentive tablets (GRT) and these tablets were manufactured by the direct compression method. The drug delivery system comprises of synthetic and semi-synthetic polymers such as polyethylene oxide and Carboxymethyl ethyl cellulose (CMEC) as release-retarding polymers. GRT were evaluated for physico-chemical properties like weight variation, hardness, assay friability, in vitro floating behaviour, swelling studies, in vitro dissolution studies and rate order kinetics. Based upon the drug release and floating properties, two formulations (MP04 & MC03) were selected as optimized formulations. The optimized formulations MP04 and MC03 followed zero order rate kinetics, with non-Fickian diffusion and first order rate kinetics with erosion mechanism, respectively. The optimized formulation was characterised with FTIR studies and it was observed that there was no interaction between the drug and polymers.info:eu-repo/semantics/openAccessInstituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del ZuliaInvestigación Clínica v.54 n.4 20132013-12-01info:eu-repo/semantics/articletext/htmlhttp://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332013000400002en
institution SCIELO
collection OJS
country Venezuela
countrycode VE
component Revista
access En linea
databasecode rev-scielo-ve
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Srikanth Meka,Venkata
Gorajana,Adinarayana
Rajan Dharmanlingam,Senthil
Murthy Kolapalli,Venkata Ramana
spellingShingle Srikanth Meka,Venkata
Gorajana,Adinarayana
Rajan Dharmanlingam,Senthil
Murthy Kolapalli,Venkata Ramana
Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
author_facet Srikanth Meka,Venkata
Gorajana,Adinarayana
Rajan Dharmanlingam,Senthil
Murthy Kolapalli,Venkata Ramana
author_sort Srikanth Meka,Venkata
title Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
title_short Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
title_full Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
title_fullStr Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
title_full_unstemmed Design and evaluation of a gastroretentive drug delivery system for metformin HCl using synthetic and semi-synthetic polymers
title_sort design and evaluation of a gastroretentive drug delivery system for metformin hcl using synthetic and semi-synthetic polymers
description The aim of the present research was to prepare and evaluate a gastroretentive drug delivery system for metformin HCl, using synthetic and semi-synthetic polymers. The floating approach was applied for preparing gastroretentive tablets (GRT) and these tablets were manufactured by the direct compression method. The drug delivery system comprises of synthetic and semi-synthetic polymers such as polyethylene oxide and Carboxymethyl ethyl cellulose (CMEC) as release-retarding polymers. GRT were evaluated for physico-chemical properties like weight variation, hardness, assay friability, in vitro floating behaviour, swelling studies, in vitro dissolution studies and rate order kinetics. Based upon the drug release and floating properties, two formulations (MP04 & MC03) were selected as optimized formulations. The optimized formulations MP04 and MC03 followed zero order rate kinetics, with non-Fickian diffusion and first order rate kinetics with erosion mechanism, respectively. The optimized formulation was characterised with FTIR studies and it was observed that there was no interaction between the drug and polymers.
publisher Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia
publishDate 2013
url http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0535-51332013000400002
work_keys_str_mv AT srikanthmekavenkata designandevaluationofagastroretentivedrugdeliverysystemformetforminhclusingsyntheticandsemisyntheticpolymers
AT gorajanaadinarayana designandevaluationofagastroretentivedrugdeliverysystemformetforminhclusingsyntheticandsemisyntheticpolymers
AT rajandharmanlingamsenthil designandevaluationofagastroretentivedrugdeliverysystemformetforminhclusingsyntheticandsemisyntheticpolymers
AT murthykolapallivenkataramana designandevaluationofagastroretentivedrugdeliverysystemformetforminhclusingsyntheticandsemisyntheticpolymers
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