Renal changes in COVID-19 infection

SUMMARY The COVID-19 (SARS-CoV-2) infection started in China, Wuhan City, Hubei Province, in December 2019, and it was declared a pandemic in mid-March 2020, caused by a new coronavirus strain called SARS-CoV-2. The pathogenesis of kidney injury attributed to SARS- CoV-2 is not well defined yet. Observations show that the kidney damage caused by the new virus mutation is mainly tubular, with impairment of glomerular filtration and high levels of urea and creatinine. A study with seriously ill patients with COVID-19 showed that acute kidney injury was present in 29%. In the face of this evidence, based on recent studies, we can see the great renal contribution as an impact factor in the evolution of COVID-19, not just as a complicator of severity, but maybe part of the initial cascade of the process, requiring a deeper analysis using conventional biomarkers of kidney injury and more aggressive clinical intervention in patients at risk, in an attempt to reduce mortality.

Bibliographic Details

Main Authors:	Duarte,Pastora Maria de Araújo, Bastos Filho,Francisco André Gomes, Duarte,João Vitor Araujo, Duarte,Beatrice Araújo, Duarte,Isabella Araujo, Lemes,Romélia Pinheiro Gonçalves, Duarte,Fernando Barroso
Format:	Digital revista
Language:	English
Published:	Associação Médica Brasileira 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001001335
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