Flow-Injection spectrophotometric system for captopril determination in pharmaceuticals

A simple, accurate and precise flow-injection spectrophotometric procedure is reported for the determination of captopril in pharmaceutical formulations. In this procedure, captopril was oxidized by iron(III) and the iron(II) produced was spectrophotometrically monitored as iron(II)-1,10-phenantroline complex at 540 nm. The analytical curve for captopril was linear in the concentration range from 1.0 × 10-5 to 8.0 × 10-4 mol L-1 with a detection limit of 5.0 × 10-6 mol L-1. The recovery of this analyte in five samples ranged from 98.5 to 102.4%. The analytical frequency was sixty determinations per hour and the RSD was less than 0.2% for a captopril concentration of 4.0 × 10-4 mol L-1 (n = 10). A paired t-test showed that all results obtained for captopril in commercial formulations using the proposed flow injection procedure and a potentiometric procedure agreed at the 95% confidence level.

Bibliographic Details

Main Authors:	Suarez,Willian T., Madi,Alexandro A., Figueiredo-Filho,Luiz C. S. de, Fatibello-Filho,Orlando
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2007
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532007000600016
Tags:	Add Tag No Tags, Be the first to tag this record!