Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative

Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative

As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.

Saved in:
Bibliographic Details
Main Authors: Peçanha,Emerson P., Fraga,Carlos A. M., Barreiro,Eliezer J., Braga,Maria F. M., Pereira,Edna F. R., Albuquerque,Edson X.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2001
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0103-50532001000300013
record_format ojs
spelling oai:scielo:S0103-505320010003000132001-10-03Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivativePeçanha,Emerson P.Fraga,Carlos A. M.Barreiro,Eliezer J.Braga,Maria F. M.Pereira,Edna F. R.Albuquerque,Edson X. 2-azabicyclo[3.3.0]octane derivatives diastereoselective reductive-amination/cyclization one-pot process nebracetam analog As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.12 n.3 20012001-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013en10.1590/S0103-50532001000300013
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Peçanha,Emerson P.
Fraga,Carlos A. M.
Barreiro,Eliezer J.
Braga,Maria F. M.
Pereira,Edna F. R.
Albuquerque,Edson X.
spellingShingle Peçanha,Emerson P.
Fraga,Carlos A. M.
Barreiro,Eliezer J.
Braga,Maria F. M.
Pereira,Edna F. R.
Albuquerque,Edson X.
Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
author_facet Peçanha,Emerson P.
Fraga,Carlos A. M.
Barreiro,Eliezer J.
Braga,Maria F. M.
Pereira,Edna F. R.
Albuquerque,Edson X.
author_sort Peçanha,Emerson P.
title Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
title_short Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
title_full Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
title_fullStr Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
title_full_unstemmed Synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
title_sort synthesis and pharmacological evaluation of a new 2-azabicyclo[3.3.0]octane derivative
description As part of a research program aiming at the design, synthesis and pharmacological evaluation of a novel lead-candidates of neuroactive compounds, we describe herein the synthesis and the central profile of a new nebracetam analog having a 2-aza-bicyclo[3.3.0]octane system. The new derivative, designed on the basis of the conformational restriction concept, was synthesized in good yields exploring a diastereoselective reductive-amination and cyclization one-pot sequence. The pharmacological profile of this new compound, investigated by using path-clamp techniques on neurons of the CNS, indicated no effects on these cells.
publisher Sociedade Brasileira de Química
publishDate 2001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300013
work_keys_str_mv AT pecanhaemersonp synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
AT fragacarlosam synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
AT barreiroeliezerj synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
AT bragamariafm synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
AT pereiraednafr synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
AT albuquerqueedsonx synthesisandpharmacologicalevaluationofanew2azabicyclo330octanederivative
_version_ 1756403147200266240

Similar Items