Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1
PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2013
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oai:scielo:S0102-865020130011000042013-12-05Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1Brasileiro,José LacerdaInoye,Celso MaschaschiAydos,Ricardo DutraSilva,Iandara SchettertFalcão,Gustavo RibeiroMarks,GuidoPereira,Daniel Martins Ischemia Reperfusion Intestine, Small Alprostadil Rats PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.28 n.11 20132013-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100004en10.1590/S0102-86502013001100004 |
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Brasileiro,José Lacerda Inoye,Celso Maschaschi Aydos,Ricardo Dutra Silva,Iandara Schettert Falcão,Gustavo Ribeiro Marks,Guido Pereira,Daniel Martins |
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Brasileiro,José Lacerda Inoye,Celso Maschaschi Aydos,Ricardo Dutra Silva,Iandara Schettert Falcão,Gustavo Ribeiro Marks,Guido Pereira,Daniel Martins Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
author_facet |
Brasileiro,José Lacerda Inoye,Celso Maschaschi Aydos,Ricardo Dutra Silva,Iandara Schettert Falcão,Gustavo Ribeiro Marks,Guido Pereira,Daniel Martins |
author_sort |
Brasileiro,José Lacerda |
title |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
title_short |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
title_full |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
title_fullStr |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
title_full_unstemmed |
Ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin E1 |
title_sort |
ischemia and reperfusion of rat small intestine using pentoxyfilline and prostaglandin e1 |
description |
PURPOSE: To investigate the small intestinal tissue alterations in rats submitted to ischemia and tissue reperfusion using pentoxyfilline or prostaglandin E1. METHODS: Thirty five Wistar rats were used, distributed into group control (A) n=10 were submitted to intestinal ischemia and reperfusion during 60 minutes and no one drug have been utilized. In the group pentoxyfilline (B) n=10 have been utilized during tissue ischemia and reperfusion as well as prostaglandin E1 (C) n=10, but separately. In the group sham (D) n=5, the animals were submitted to surgical. After euthanasia of the animals, a segment of the small intestine was cut, stained by hematoxilin-eosin and histological analysis according to Chiu criteria. RESULTS: Histological results showed that using pentoxyflline or prostaglandin E1 the results during tissue reperfusion were better, since the levels of criteria from Chiu that predominated were level 2 and 3, indicating less tissue damage in comparison to the control group (group A) that showed levels 4 and 5, what means more severe histological tissue alterations. CONCLUSION: Use of pentoxyfilline or prostaglandin E1 promoted a beneficial effect during intestinal reperfusion, demonstrated by less severe histological lesions in the small intestine mucosa of rats submitted to ischemia and tissue reperfusion when helped by the drugs. |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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2013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502013001100004 |
work_keys_str_mv |
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1756400937100902400 |