Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).
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Sociedade Brasileira de Farmacognosia
2012
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200018 |
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oai:scielo:S0102-695X20120002000182012-05-08Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianusCabral,Rodrigo S.Sartori,Maura C.Cordeiro,InêsQueiroga,Carmen L.Eberlin,Marcos N.Lago,João H. G.Moreno,Paulo R. H.Young,Maria C. M. acetylcholinesterase inhibitors, alkaloids Conchocarpus fontanesianus coumarin Rutaceae Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5).info:eu-repo/semantics/openAccessSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.22 n.2 20122012-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200018en10.1590/S0102-695X2011005000219 |
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Cabral,Rodrigo S. Sartori,Maura C. Cordeiro,Inês Queiroga,Carmen L. Eberlin,Marcos N. Lago,João H. G. Moreno,Paulo R. H. Young,Maria C. M. |
| spellingShingle |
Cabral,Rodrigo S. Sartori,Maura C. Cordeiro,Inês Queiroga,Carmen L. Eberlin,Marcos N. Lago,João H. G. Moreno,Paulo R. H. Young,Maria C. M. Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| author_facet |
Cabral,Rodrigo S. Sartori,Maura C. Cordeiro,Inês Queiroga,Carmen L. Eberlin,Marcos N. Lago,João H. G. Moreno,Paulo R. H. Young,Maria C. M. |
| author_sort |
Cabral,Rodrigo S. |
| title |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_short |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_full |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_fullStr |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_full_unstemmed |
Anticholinesterase activity evaluation of alkaloids and coumarin from stems of Conchocarpus fontanesianus |
| title_sort |
anticholinesterase activity evaluation of alkaloids and coumarin from stems of conchocarpus fontanesianus |
| description |
Conchocarpus fontanesianus (A. St.-Hill.) Kallunki & Pirani, Rutaceae, popularly known as pitaguará, is a native and endemic tree from São Paulo and Rio de Janeiro States, Brazil. Based in the information that anticholinesterasic derivatives could act as new prototypes to treatment of Alzheimer disease, this work describes the fractionation guided by evaluation of the anticholinesterase activity of the ethanolic stems extract from C. fontanesianus. This procedure afforded the alkaloids dictamnine (1), γ-fagarine (2), skimianine (3), and 2-phenyl-1-methyl-4-quinolone (4), as well as the coumarin marmesin (5). |
| publisher |
Sociedade Brasileira de Farmacognosia |
| publishDate |
2012 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200018 |
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