Free omental graft without vascular microanastomosis in the cutaneous wound healing of rabbits
ABSTRACT This study aims to evaluate the influence of free omental graft without vascular microanastomosis (FOGWVA) on experimental skin healing in rabbits. Through celiotomy, a 9cm2 free omental fragment was collected in 36 rabbits, with subsequent production of a deep linear cutaneous wound in the dorsal midline measuring 3cm. In 18 animals from the omental group (OG), the omental fragment collected was fixed subcutaneously with six simple interrupted stitches using a 4-0 polyamide thread. In both treated and control (CG) groups, intradermal dermorrhaphy was performed with 4-0 polyamide thread. Experimental wounds were clinically evaluated every day. Each of the groups was divided into three subgroups of 6 animals each for histopathological evaluation on the 7th, 14th, and 28th days of postoperative. In the OG wounds, the increase in volume (omentum activation) stood out after the second postoperative day. Macroscopy showed an organic reaction to the graft on day 7, with a progressive reduction in addition to neovascularization towards the omental graft. The intense presence of mononuclear cells and collagen deposition on day 7 demonstrated an accelerated process of tissue remodeling and repair. The FOGWVA omental graft remained viable and positively influenced the cutaneous healing of the experimental wounds in rabbits.
Main Authors: | Fernandes,M.E.S.L., Peixoto,A.J.R., Campo,A.C.S., Borges,D.A., Pereira,G.O., Oliveira,J., Oliveira,L.M.S., Nogueira,V.A., Jorge,S.F., Silva,M.F.A. |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Universidade Federal de Minas Gerais, Escola de Veterinária
2022
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352022000500785 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Behavior of free omental grafts without vascular anastomosis implanted in cat’s experimental wounds
by: Teixeira,Jorge Gabriel de Cerqueira, et al.
Published: (2020) -
Phototherapy promotes healing of cutaneous wounds in undernourished rats
by: Leite,Saulo Nani, et al.
Published: (2014) -
Influence of protein malnutrition on cutaneous wound healing in rats
by: SAMPAIO,Laura Amélia Santos, et al.
Published: (2018) -
Lamellar keratoplasty in rabbits using an allogeneic free omental graft and omentum-derived mesenchymal cells associated with the canine amniotic membrane
by: Barros,Séfora Vieira da Silva Gouvêa de, et al.
Published: (2016) -
Amniotic membrane as a biological dressing in infected wound healing in rabbits
by: Duarte,Ian Göedert Leite, et al.
Published: (2014)